PROTAC Linker

Total: 1884
Updated: 2019-06-28 15:55:20
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.
The PROTAC linker connects two moieties: a small peptide residue for E3 ubiquitin ligase recognition,and a ligand that can be recognized by a targeted protein. Unlike the small molecule ligands, the length of the linker has been randomly selected for PROTACs, varying from 12-carbon to over 20-carbon in length. An optimal linker will allow for maximal interaction between the two moieties (target protein and E3 ligase) resulting in efficient ubiquitination of the target protein and its ultimate degradation.

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PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
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Tos-PEG4-CH2-Boc

Tos-PEG4-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 169751-73-9
  • MF: C21H34O9S
  • MW: 462.554
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 550.0±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 286.4±30.1 °C
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Aminooxy-PEG1-azide

Aminooxy-PEG1-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 2100306-70-3
  • MF: C4H10N4O2
  • MW: 146.15
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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NH2-PEG5-OH

NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

  • CAS Number: 34188-11-9
  • MF: C10H23NO5
  • MW: 237.293
  • Catalog: ADC Linker
  • Density: 1.1±0.0 g/cm3
  • Boiling Point: 346.3±0.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 163.2±0.0 °C
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Bromo-PEG4-acid

Bromo-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1393330-38-5
  • MF: C11H21BrO6
  • MW: 329.185
  • Catalog: PROTAC Linker
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 426.9±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 212.0±27.3 °C
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Boc-N-PEG2-Ms

Boc-N-PEG2-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 302331-20-0
  • MF: C10H21NO6S
  • MW: 283.34200
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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(±)15-HETE

(±)15-HETE is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 71030-36-9
  • MF: C20H32O3
  • MW: 320.466
  • Catalog: PROTAC Linker
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 487.7±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 262.8±25.2 °C
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Propargyl-PEG1-acrylate

Propargyl-PEG1-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 52436-42-7
  • MF: C8H10O3
  • MW: 154.163
  • Catalog: PROTAC Linker
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 214.9±15.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 81.7±15.0 °C
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Tos-PEG2-Boc

Tos-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1309666-78-1
  • MF: C16H24O6S
  • MW: 344.423
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 460.6±30.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 232.3±24.6 °C
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Bis-Tos-PEG7

Bis-Tos-PEG7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 69502-27-8
  • MF: C28H42O12S2
  • MW: 634.75600
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Hydroxy-PEG4-methylamine

Hydroxy-PEG4-methylamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 90430-59-4
  • MF: C9H21NO4
  • MW: 207.26700
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Bis-PEG2-acid

Bis-PEG2-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 19364-66-0
  • MF: C8H14O6
  • MW: 206.19300
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Benzyloxy carbonyl-PEG3-acid

Benzyloxy carbonyl-PEG3-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2100306-73-6
  • MF: C17H24O7
  • MW: 340.37
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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DBCO-PEG4-NHS ester

DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1427004-19-0
  • MF: C34H39N3O10
  • MW: 649.688
  • Catalog: PROTAC Linker
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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N-Dbco-N-bis(peg2-nhs ester)

N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2128735-29-3
  • MF: C41H46N4O14
  • MW: 818.82
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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T-Boc-aminooxy-peg4-ch2co2-t-bu

Boc-Aminooxy-PEG4-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2062663-63-0
  • MF: C19H37NO9
  • MW: 423.50
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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m-PEG6-Tos

m-PEG6-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 155887-96-0
  • MF: C20H34O9S
  • MW: 450.54
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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tert-Butyl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15-pentaoxaoctadecan-18-oate

Mal-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2250216-91-0
  • MF: C21H35NO9
  • MW: 445.50
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-amido-PEG6-acid

Mal-amido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1334177-79-5
  • MF: C22H36N2O11
  • MW: 504.528
  • Catalog: PROTAC Linker
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 702.5±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 378.7±32.9 °C
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Amino-PEG12-alcohol

Amino-PEG12-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1345681-71-1
  • MF: C24H51NO12
  • MW: 545.661
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 596.5±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 314.6±28.7 °C
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Biotin-PEG3-azide

Biotin-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

  • CAS Number: 875770-34-6
  • MF: C18H32N6O5S
  • MW: 444.549
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 110 °C
  • Flash Point: N/A
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Br-PEG4-OH

Br-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 85141-94-2
  • MF: C8H17BrO4
  • MW: 257.12200
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Aminooxy-PEG1-propargyl HCl

Aminooxy-PEG1-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

  • CAS Number: 1895922-69-6
  • MF: C5H9NO2
  • MW: 115.13
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Biotin-PEG2-C1-aldehyde

Biotin-PEG2-C1-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2408505-11-1
  • MF: C16H27N3O5S
  • MW: 373.47
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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T-Boc-aminoxy-peg4-alcohol

Boc-Aminoxy-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 918132-14-6
  • MF: C13H27NO7
  • MW: 309.35600
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Biotin-PEG11-azide

Biotin-PEG-azide (MW 1000) is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].

  • CAS Number: 956494-20-5
  • MF: C17H34N4O7
  • MW: 406.474
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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L-Homopropargylglycine

L-Homopropargylglycine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 98891-36-2
  • MF: C6H9NO2
  • MW: 127.14100
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Mal-PEG4-C2-NH2 TFA

Mal-PEG4-C2-NH2 TFA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2512227-13-1
  • MF: C16H25F3N2O8
  • MW: 430.37
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Methyl-PEG12-Azide

m-PEG12-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2170098-29-8
  • MF: C25H51N3O12
  • MW: 585.69
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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Boc-Aminooxy-PEG2

Boc-Aminooxy-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 1807503-86-1
  • MF: C9H19NO5
  • MW: 221.251
  • Catalog: PROTAC Linker
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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T-Boc-n-amido-peg5-ms

Boc-N-Amido-PEG5-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

  • CAS Number: 2128735-28-2
  • MF: C16H33NO9S
  • MW: 415.50
  • Catalog: PROTAC Linker
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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