Amyloid-β (Aβ) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of theamyloid plaques found in the brains of Alzheimer patients. The peptides result from the amyloid precursor protein (APP), which is being cut by certain enzymes to yield Aβ. Amyloid-β molecules can aggregate to form flexible soluble oligomers which may exist in several forms. Amyloid-β peptide is due to overproduction of Aβ and/or the failure of clearance mechanisms. Amyloid-β self-aggregates into oligomers, which can be of various sizes, and forms diffuse and neuritic plaques in the parenchyma and blood vessels. Amyloid-β oligomers and plaques are potent synaptotoxins, block proteasome function, inhibit mitochondrial activity, alter intracellular Ca2+levels and stimulate inflammatory processes. Loss of the normal physiological functions of Aβ is also thought to contribute to neuronal dysfunction.


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Amyloid β-Protein (1-15) trifluoroacetate salt

β-Amyloid (1-15) is a fragment of β-Amyloid peptide. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.

  • CAS Number: 183745-81-5
  • MF: C78H107N25O27
  • MW: 1826.85
  • Catalog: Peptides
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Amyloid β-Protein (1-11)

β-amyloid (1-11) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.

  • CAS Number: 190436-05-6
  • MF: C56H76N16O22
  • MW: 1325.3
  • Catalog: Peptides
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Amyloid β-Protein (12-28)

β-amyloid (12-28) is a 17-aa peptide fragment, which can produce amyloid aggregates, used in the research of Alzheimer’sdisease.

  • CAS Number: 107015-83-8
  • MF: C89H135N25O25
  • MW: 1955.18000
  • Catalog: Peptides
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

gamma-Secretase Modulators

gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. gamma-Secretase Modulators is useful for Alzheimer's disease.IC50 value:Target: γ-secretase modulator

  • CAS Number: 937812-80-1
  • MF: C26H24F3N3O3
  • MW: 483.48200
  • Catalog: Amyloid-β
  • Density: 1.37g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Tramiprosate

Tramiprosate is a small, orally-administered compound that binds to soluble Aβ and reduces amyloid aggregation and subsequent depositiontarget: AβIn vitro: Tramiprosate provides neuroprotection against Aβ-induced neurotoxicity in neuronal and mouse organotypic hippocampal cultures, and reverses Aβ-induced long-term potentiation (LTP) inhibition in rat hippocampus, in part, through activation of β-aminobutyric acid A (GABA-A) receptors. Tramiprosate dose-dependently provides neuroprotection against ischemic stroke.In vivo: Tramiprosate produced dose-dependent reductions of Aβ in the brain of transgenic mice (hAPP-TgCRND8). Clinical studies show that tramiprosate was safe and tolerable. In mild-to-moderate AD patients tramiprosate also reduced Aβ42 levels in CSF.The reference for animal administration is 50 mg/kg.

  • CAS Number: 3687-18-1
  • MF: C3H9NO3S
  • MW: 139.173
  • Catalog: Amyloid-β
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: 293 °C (dec.)(lit.)
  • Flash Point: N/A

Edonerpic maleate

Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).

  • CAS Number: 519187-97-4
  • MF: C20H25NO6S
  • MW: 407.481
  • Catalog: Amyloid-β
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Amyloid β-Protein (25-35) trifluoroacetate salt

Amyloid beta-peptide(25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells.

  • CAS Number: 131602-53-4
  • MF: C45H81N13O14S
  • MW: 1060.27000
  • Catalog: Peptides
  • Density: 1.249g/cm3
  • Boiling Point: 1517.336ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 871.453ºC

HOECHST 34580

Hoechst 34580 is a cell-permeable fluorescent dye for staining DNA and nuclei.

  • CAS Number: 23555-00-2
  • MF: C27H29N7
  • MW: 451.57
  • Catalog: Dye Reagents
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Ginsenoside Re

Ginsenoside Re is an extract from Panax notoginseng. Ginsenoside Re decreases the β-amyloid protein (Aβ). Ginsenoside Re plays a role in antiinflammation through inhibition of JNK and NF-κB.

  • CAS Number: 52286-59-6
  • MF: C48H82O18
  • MW: 947.154
  • Catalog: JNK
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 1011.8±65.0 °C at 760 mmHg
  • Melting Point: 202 °C(dec.)
  • Flash Point: 565.7±34.3 °C

Amyloid β-Protein (22-35)

β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and induces neurotoxicity in the hippocampal cells.

  • CAS Number: 144189-71-9
  • MF: C59H102N16O21S
  • MW: 1403.60000
  • Catalog: Peptides
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

amyloid P-IN-1

pharmaceutical compositions comprising the same and the use of the same for treatment of diseases or disorders wherein depletion of serum amyloid P component (SAP) would be beneficial, including amyloidosis, Alzheimer's disease, type 2 diabetes mellitus and osteoarthritis.

  • CAS Number: 1819986-22-5
  • MF: C30H44N2O14
  • MW: 656.68
  • Catalog: Amyloid-β
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Frentizole

Frentizole, an FDA-approved immunosuppressive drug, is a novel inhibitor of the Aβ-ABAD interaction.IC50 value:Target: Aβ-ABAD interaction

  • CAS Number: 26130-02-9
  • MF: C15H13N3O2S
  • MW: 299.34800
  • Catalog: Amyloid-β
  • Density: 1.42g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Colivelin trifluoroacetate salt

Colivelin is a neuroprotective peptide and activator of STAT3.

  • CAS Number: 867021-83-8
  • MF: C119H206N32O35
  • MW: 2645.10000
  • Catalog: Peptides
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

β-Amyloid-42

Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

  • CAS Number: 107761-42-2
  • MF: C203H311N55O60S
  • MW: 4514.04000
  • Catalog: Amyloid-β
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Geniposide

Geniposide is an iridoid glucoside extracted from Gardenia jasminoides Ellis fruits; exhibits a varity of biological activities such as anti-diabetic, antioxidative, antiproliferative and neuroprotective activities.

  • CAS Number: 24512-63-8
  • MF: C17H24O10
  • MW: 388.366
  • Catalog: Amyloid-β
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 641.4±55.0 °C at 760 mmHg
  • Melting Point: 161-162ºC
  • Flash Point: 231.5±25.0 °C

β-Amyloid (10-35), amide

β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.

  • CAS Number: 181427-66-7
  • MF: C133H205N35O36S
  • MW: 2902.33
  • Catalog: Peptides
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

K 01-162

K 01-162 (K162) binds and destabilizes AβO (β-amyloid), with an EC50 of 80 nM. IC50 value: 80 nM (EC50)Target: Amyloid-βin vitro: The active drug candidate K162 (EC50 = 0.080 μM), stabilizes hydrophobic core I of Aβ42 peptide (residues 17-21) to its α-helical conformation by interacting specifically in this region. [1] K01-162 shows full MC65 protection at 125 nM, an EC50 of 80 nM, and no cytotoxicity up to 50 μM. [2]in vivo:K01-162 can reduce the brain amyloid burden that exists in both fibrillar and RIPA-soluble, non-fibrillar forms.[2]

  • CAS Number: 677746-25-7
  • MF: C15H14BrN
  • MW: 288.18200
  • Catalog: Amyloid-β
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

BF-168

BF-168, a candidate probe for PET, is found to specifically recognize both neuritic and diffuse plaques, with a Ki of 6.4 nM for Aβ1-42.

  • CAS Number: 634911-47-0
  • MF: C18H17FN2O2
  • MW: 312.34
  • Catalog: Amyloid-β
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Amyloid β-Protein (42-1)

Amyloid β Peptide (42-1)(human) is the inactive form of Amyloid β Peptide (1-42). Amyloid β Peptide (42-1) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

  • CAS Number: 317366-82-8
  • MF: C203H311N55O60S
  • MW: 4514.106
  • Catalog: Peptides
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Ginsenoside Rg3

Ginsenoside Rg3 is the main component of Red ginseng. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.

  • CAS Number: 14197-60-5
  • MF: C42H72O13
  • MW: 785.013
  • Catalog: COX
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 885.0±65.0 °C at 760 mmHg
  • Melting Point: 315-318°C
  • Flash Point: 489.0±34.3 °C

Amyloid β-Protein (1-16) trifluoroacetate salt

β-Amyloid (1-16) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.

  • CAS Number: 131580-10-4
  • MF: C84H119N27O28
  • MW: 1955.04
  • Catalog: Peptides
  • Density: 1.6±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Schisantherin B

Schisantherin B is a natural product.

  • CAS Number: 58546-55-7
  • MF: C28H34O9
  • MW: 514.564
  • Catalog: Amyloid-β
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 675.0±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 220.3±25.0 °C

DWK-1339

DWK-1339 is an orally active and blood-brain-barrier-permeable Aβ-aggregation inhibitor, used in the research of Alzheimer's disease.

  • CAS Number: 1018946-38-7
  • MF: C20H22O4
  • MW: 326.38600
  • Catalog: Amyloid-β
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Amyloid β-Protein (29-40)

β-Amyloid (29-40) is a fragment of Amyloid-β peptide.

  • CAS Number: 184865-04-1
  • MF: C49H88N12O13S
  • MW: 1085.36000
  • Catalog: Peptides
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Semagacestat(LY450139)

Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid (Aβ42), Aβ38 and Aβ40 with IC50 of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC50 of 14.1 nM.

  • CAS Number: 425386-60-3
  • MF: C19H27N3O4
  • MW: 361.435
  • Catalog: Amyloid-β
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 681.9±55.0 °C at 760 mmHg
  • Melting Point: 208-212°C
  • Flash Point: 366.2±31.5 °C

ARN2966

ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ. IC50 value: Target: AβThis potent post-transcriptional modulation of APP expression differs from other mechanisms such as inhibition of secretases. Secretase inhibitors have been pursued as disease modifying strategies by a number of pharmaceutical firms but they have encountered numerous setbacks during clinical development. ARN2966 is non toxic, orally absorbable, blood-brain-barrier penetrable, and effective in vitro and in vivo.

  • CAS Number: 102212-26-0
  • MF: C12H12N2O
  • MW: 200.23600
  • Catalog: Amyloid-β
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Deferoxamine (mesylate)

Deferoxamine mesylate is an iron chelator that binds free iron in a stable complex, preventing it from engaging in chemical reactions.

  • CAS Number: 138-14-7
  • MF: C26H52N6O11S
  • MW: 752.895
  • Catalog: Autophagy
  • Density: N/A
  • Boiling Point: 966.9ºC at 760 mmHg
  • Melting Point: 148-149°
  • Flash Point: 538.5ºC

Amyloid β-Protein (1-42) (mouse, rat)

β-Amyloid (1-42), rat is a 42-aa peptide, shows cytotoxic effect on acute hippocampal slices, and used in the research of Alzheimer's disease.

  • CAS Number: 166090-74-0
  • MF: C199H307N53O59S
  • MW: 4418.017
  • Catalog: Peptides
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Ginsenoside Rg1

Ginsenoside Rg1 is one of the major active components of ginseng. Ginsenoside Rg1 displays promising effects by reducing cerebral Aβ levels. Ginsenoside Rg1 also reduces NF-κB nuclear translocation.

  • CAS Number: 22427-39-0
  • MF: C42H72O14
  • MW: 801.013
  • Catalog: Amyloid-β
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 898.5±65.0 °C at 760 mmHg
  • Melting Point: 194~197 ℃
  • Flash Point: 497.2±34.3 °C

Latrepirdine

Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.

  • CAS Number: 97657-92-6
  • MF: C21H27Cl2N3
  • MW: 392.365
  • Catalog: Autophagy
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A