184865-04-1

184865-04-1 structure

Name	amyloid β-protein(30-40)
Synonyms	Aβ(30-40) β-Amyloid (29-40)

Description	β-Amyloid (29-40) is a fragment of Amyloid-β peptide.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Amyloid-β Peptides Research Areas >> Neurological Disease
Target	Amyloid-β[1]
In Vitro	β-Amyloid (29-40) is a fragment of Amyloid-β peptide, unsoluble in water, acetonitrile or in a mixture of both in different ratios. Cationic arginine residues is introduced at β-Amyloid (29-40) C-terminus to solubilize β-Amyloid (29-40) and introduce cationicity in this Aβ stretch to enable it to interact with the negatively charged membrane of bacteria. β-Amyloid (29-40) variants shows antimicrobial effect[1]. Single chain variable fragments (scFv's) binds the 17-28 region of Abeta and effectively inhibits in vitro aggregation of Abeta, but binding the carboxyl-terminal region of β-Amyloid (29-40) does not inhibit aggregation[2].
References	[1]. Harioudh MK, et al. A short non-cytotoxic antimicrobial peptide designed from Aβ29-40 adopts a nanostructure and shows in vivo anti-endotoxin activity. Chem Commun (Camb). 2017 Dec 5;53(97):13079-13082. [2]. Liu R, et al. Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity. Biochemistry. 2004 Jun 8;43(22):6959-67.