102212-26-0

102212-26-0 structure

Name: ARN2966
Chemical Name: N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)amine
CAS Number: 102212-26-0
Molecular Formula: C₁₂H₁₂N₂O
Molecular Weight: 200.23600
Catalog: Signaling Pathways Neuronal Signaling Amyloid-β
Create Date: 2018-06-21 12:27:34
Modify Date: 2025-08-29 21:46:19
ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ. IC50 value: Target: AβThis potent post-transcriptional modulation of APP expression differs from other mechanisms such as inhibition of secretases. Secretase inhibitors have been pursued as disease modifying strategies by a number of pharmaceutical firms but they have encountered numerous setbacks during clinical development. ARN2966 is non toxic, orally absorbable, blood-brain-barrier penetrable, and effective in vitro and in vivo.

Name	N-(2-hydroxyphenyl)-N-(2-pyridylmethyl)amine
Synonyms	2-[(Pyridin-2-ylmethyl)-amino]-phenol 2-N-(2-pyridylmethyl)aminophenol (2-Hydroxyphenyl)(2-pyridylmethyl)amin 2-[(pyridine-2-ylmethyl)-amino]phenol ARN2966 2-PMAP

Description	ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ. IC50 value: Target: AβThis potent post-transcriptional modulation of APP expression differs from other mechanisms such as inhibition of secretases. Secretase inhibitors have been pursued as disease modifying strategies by a number of pharmaceutical firms but they have encountered numerous setbacks during clinical development. ARN2966 is non toxic, orally absorbable, blood-brain-barrier penetrable, and effective in vitro and in vivo.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Amyloid-β Research Areas >> Neurological Disease
References	[1]. http://arianeurosciences.com/science.html

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport