Na+/Ca2+ Exchanger

Total: 6
Updated: 2019-06-28 15:55:20
Na+/Ca2+ exchanger (sodium-calcium exchanger , NCX) is an antiporter membrane protein that removes calcium from cells. It uses the energy that is stored in the electrochemical gradient of sodium (Na+) by allowing Na+ to flow down its gradient across the plasma membrane in exchange for the countertransport of calcium ions (Ca2+). Na+/Ca2+ exchanger removes a single calcium ion in exchange for the import of three sodium ions. Na+/Ca2+ exchanger exists in many different cell types and animal species. Na+/Ca2+ exchanger is considered one of the most important cellular mechanisms for removing Ca2+. The Na+/Ca2+ exchanger does not bind very tightly to Ca2+ (has a low affinity), but it can transport the ions rapidly (has a high capacity), transporting up to five thousand Ca2+ ions per second. The Na+/Ca2+ exchanger also likely plays an important role in regaining the cell's normal calcium concentrations after an excitotoxic insult.

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SM-6586

SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.

  • CAS Number: 103898-38-0
  • MF: C26H27N5O5
  • MW: 489.52300
  • Catalog: Calcium Channel
  • Density: 1.31g/cm3
  • Boiling Point: 561.3ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 293.3ºC
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CGP 37157

CGP37157 is a potent, selective inhibitor of Na+/Ca2+ exchanger, inhibiting the Na+-induced Ca2+-release from guinea-pig heart mitochondria, with an IC50 of 0.8 μM.

  • CAS Number: 75450-34-9
  • MF: C15H11Cl2NOS
  • MW: 324.225
  • Catalog: Na+/Ca2+ Exchanger
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 479.8±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 244.0±28.7 °C
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KB-R7943 mesylate

KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 µM.

  • CAS Number: 182004-65-5
  • MF: C17H21N3O6S2
  • MW: 427.495
  • Catalog: Na+/Ca2+ Exchanger
  • Density: N/A
  • Boiling Point: 534.6ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 277.1ºC
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SN6

SN 6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor, and inhibits 45Ca2+ uptake by NCX1, NCX2, and NCX3, with IC50s of 2.9, 16, and 8.6 μM, respectively.

  • CAS Number: 415697-08-4
  • MF: C20H22N2O5S
  • MW: 402.46400
  • Catalog: Na+/Ca2+ Exchanger
  • Density: 1.285g/cm3
  • Boiling Point: 581.2ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 305.3ºC
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Caldaret

Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition.

  • CAS Number: 133804-44-1
  • MF: C11H16N2O3S
  • MW: 256.32100
  • Catalog: Na+/Ca2+ Exchanger
  • Density: 1.302g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
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SEA-0400

SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX), inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM.

  • CAS Number: 223104-29-8
  • MF: C21H19F2NO3
  • MW: 371.377
  • Catalog: Na+/Ca2+ Exchanger
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 485.0±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 247.1±28.7 °C
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