RSV (Respiratory syncytial virus) is a virus that causes respiratory tract infections. RSV is a negative-sense, single-stranded RNA virus of the family Paramyxoviridae, which includes common respiratory viruses such as those causingmeasles and mumps. RSV is a member of the paramyxovirus subfamily Pneumovirinae. RSV is a major cause of lower respiratory tract infections and hospital visits during infancy and childhood.


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4-Methoxycinnamaldehyde

4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde), an active constituent of Agastache rugosa, exhibits cytoprotective activity against respiratory syncytial virus (RSV) in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde effectively inhibits cytopathic effect of RSV with an estimated IC50 of 0.055 μg/mL[1].

  • CAS Number: 1963-36-6
  • MF: C10H10O2
  • MW: 162.185
  • Catalog: RSV
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 308.7±17.0 °C at 760 mmHg
  • Melting Point: 55-60ºC(lit.)
  • Flash Point: 146.5±14.5 °C

Enzaplatovir

Enzaplatovir (BTA-585, BTA-C585) is an orally bioavailable RSV fusion protein inhibitor for the treatment of respiratory syncytial virus infections. RSV Infection Phase 2 Discontinued

  • CAS Number: 1323077-89-9
  • MF: C20H19N5O3
  • MW: 377.397
  • Catalog: RSV
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 663.0±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 354.8±31.5 °C

Ziresovir

Ziresovir (AK0529;RO-0529) is a potent, selective, and orally bioavailable respiratory syncytial virus (RSV) fusion (F) protein (RSV F) protein inhibitor. Ziresovir shows anti-RSV activity (EC50=3 nM) and highlights pharmacokinetics in animal species[1].

  • CAS Number: 1422500-60-4
  • MF: C22H25N5O3S
  • MW: 439.531
  • Catalog: RSV
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 745.4±70.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 404.6±35.7 °C

(S)-Enzaplatovir

(S)-Enzaplatovir ((S)-BTA-C585) is the S-enantiomer of Enzaplatovir. (S)-Enzaplatovir shows antiviral activities with an EC50 of 56 nM for respiratory syncytial viral (RSV) (patent WO2011094823A1 compound 77)[1].

  • CAS Number: 1323077-88-8
  • MF: C20H19N5O3
  • MW: 377.40
  • Catalog: RSV
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Clesrovimab

Clesrovimab (MK1654) is a fully human, anti-RSV fusion (RSV F) glycoprotein monoclonal antibody. Clesrovimab has the potential for the research of respiratory syncytial virus infection[1][2].

  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Sophoranol

Sophoranol is an alkaloid that can be isolated from S. flavescens, with antiviral activity. Sophoranol has anti-HBV (hepatitis B virus) activity. Sophoranol shows potent antiviral activities against respiratory syncytial virus (RSV) with an IC50 of 10.4 μg/mL[1][2].

  • CAS Number: 3411-37-8
  • MF: C15H24N2O2
  • MW: 264.36300
  • Catalog: HBV
  • Density: 1.25
  • Boiling Point: N/A
  • Melting Point: 169-170 ºC
  • Flash Point: N/A

RSV604 R enantiomer

RSV604 R enantiomer is the R-enantiomer of RSV604. RSV604 is an inhibitor of respiratory syncytial virus (RSV) replication. R-enantiomer is less active against RSV.

  • CAS Number: 932108-20-8
  • MF: C22H17FN4O2
  • MW: 388.39
  • Catalog: RSV
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

4,5-Di-O-caffeoylquinic acid methyl ester

4,5-O-Dicaffeoyl quinic acid methyl ester (compound 4), a dicaffeoylquinic acid, has potent antiviral activity against respiratory syncytial virus (RSV) with an IC50 of 0.63 μg/mL and a CC50 of 118.68 μg/mL.

  • CAS Number: 188742-80-5
  • MF: C26H26O12
  • MW: 530.48
  • Catalog: RSV
  • Density: 1.6±0.1 g/cm3
  • Boiling Point: 740.7±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 247.1±26.4 °C

Presatovir

Presatovir (GS-5806) is a novel, orally bioavailable RSV fusion inhibitor with a mean EC50 value of 0.43 nM.

  • CAS Number: 1353625-73-6
  • MF: C24H30ClN7O3S
  • MW: 532.058
  • Catalog: RSV
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Suptavumab

Suptavumab (REGN2222) is a human monoclonal antibody. Suptavumab can bind and block a conserved epitope on RSV A and B subtypes. Suptavumab can be used for the research of RSV infection[1][2].

  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

palivizumab

Palivizumab (MEDI 493), a humanized respiratory syncytial virus monoclonal antibody, reduces respiratory syncytial virus (RSV) infection[1].

  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

GS-443902

GS-443902 (Remdesivir metabolite) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 5.6 µM, 1.1 µM, 5 µM for TP RdRp, RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir[1][2].

  • CAS Number: 1355149-45-9
  • MF: C12H16N5O13P3
  • MW: 531.202
  • Catalog: HCV
  • Density: 2.4±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

RSV-IN-6

RSV-IN-6 (Compound 53) is an anti-RSV agent targeting M2-1 protein with EC50 values of 4.4 μM and 1.3 μM against RSV-A and RSV-B strain, respectively[1].

  • CAS Number: 2415152-41-7
  • MF: C19H19N3S3
  • MW: 385.57
  • Catalog: RSV
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Antiviral agent 30

Antiviral agent 30 (Example 118) is an antiviral agent. Antiviral agent 30 is active against HCV and RSV (IC50: > 25μM)[1].

  • CAS Number: 381731-49-3
  • MF: C21H32N2O3S
  • MW: 392.56
  • Catalog: HCV
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

RSV604 racemate

RSV604 racemate is a racemic mixture, shows less potency against strains of respiratory syncytial virus (RSV) than the S-isomer.

  • CAS Number: 676128-62-4
  • MF: C22H17FN4O2
  • MW: 388.394
  • Catalog: RSV
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 575.0±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 301.6±30.1 °C

Ribavirin

Ribavirin is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV.

  • CAS Number: 36791-04-5
  • MF: C8H12N4O5
  • MW: 244.205
  • Catalog: HCV
  • Density: 2.1±0.1 g/cm3
  • Boiling Point: 639.8±65.0 °C at 760 mmHg
  • Melting Point: 174-176°C
  • Flash Point: 340.7±34.3 °C

RSV-604

RSV604 is a novel inhibitor of respiratory syncytial virus replication(EC50=0.86 uM); a putative RSV nucleoprotein(N) inhibitor in phase 2 clinical trials.IC50 value: 0.86 uM(EC50) [1]Target: RSV inhibitorRSV604, a novel benzodiazepine with submicromolar anti-RSV activity. It proved to be equipotent against all clinical isolates tested of both the A and B subtypes of the virus. The compound has a low rate of in vitro resistance development. Sequencing revealed that the resistant virus had mutations within the nucleocapsid protein. This is a novel mechanism of action for anti-RSV compounds. In a three-dimensional human airway epithelial cell model, RSV604 was able to pass from the basolateral side of the epithelium effectively to inhibit virus replication after mucosal inoculation. RSV604, which is currently in phase II clinical trials, represents the first in a new class of RSV inhibitors and may have significant potential for the effective treatment of RSV disease.

  • CAS Number: 676128-63-5
  • MF: C22H17FN4O2
  • MW: 388.39400
  • Catalog: RSV
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

8-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-6,6-dimethyl-2-(4-methyl-3-nitrophenyl)-1H-imidazo[4,5-h]isoquinoline-7,9(6H,8H)-dione1H-imidazo[4,5-h]isoquinoline-7,9(6H,8H)-dione

RSV L-protein-IN-4 (Compound C) is a noncompetitive RSV polymerase inhibitor (IC50: 0.88 μM). RSV L-protein-IN-4 shows antiviral activity against RSV strains (EC50: 0.25 μM)[1].

  • CAS Number: 851657-60-8
  • MF: C32H35N5O6
  • MW: 585.65
  • Catalog: RSV
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Quercetin pentaacetate

Quercetin pentaacetate could interact with F-protein with lower binding energy and better stability to block viral adhesion. Quercetin pentaacetate interacts with RSV and inhibit the viral adhesion on cell surface[1][2].

  • CAS Number: 1064-06-8
  • MF: C25H20O12
  • MW: 512.41900
  • Catalog: Fungal
  • Density: 1.45g/cm3
  • Boiling Point: 666.4ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 284.7ºC

GS-443902 trisodium

GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734)[1][2].

  • CAS Number: 1355050-21-3
  • MF: C12H13N5Na3O13P3
  • MW: 597.15
  • Catalog: HCV
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

TMC353121

TMC353121 is a potent respiratory syncytial virus (RSV) fusion inhibitor with pEC50 of 9.9.

  • CAS Number: 857066-90-1
  • MF: C32H42N6O3
  • MW: 558.71400
  • Catalog: RSV
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

4'-C-Fluoro-uridine

EIDD-2749 (4'-Fluorouridine) is an orally active, low cytotoxic and broad-spectrum mononegavirus inhibitor (SI≥1877). EIDD-2749 effectively blocks the replication of respiratory syncytial virus (RSV) and SARS-CoV-2. EIDD-2749 can be used in the study of RSV, SARSCoV-2 and related RNA virus infections[1].

  • CAS Number: 1613589-24-4
  • MF: C9H11FN2O6
  • MW: 262.19
  • Catalog: HCV
  • Density: 1.77±0.1 g/cm3(Predicted)
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

ALS-8112

ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase with an IC50 of 0.02 μM.

  • CAS Number: 1445379-92-9
  • MF: C10H13ClFN3O4
  • MW: 293.679
  • Catalog: RSV
  • Density: 1.8±0.1 g/cm3
  • Boiling Point: 532.8±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 276.0±32.9 °C

Felvizumab

Felvizumab (SB 209763) is a humanized IgG1κ monoclonal antibody directed to distinct neutralizing epitopes on the F glycoprotein of RSV[1][2].

  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

RFI-641

RFI-641 is a dendrimer-like compound with anti-RSV properties and is effective in vitro and in vivo activity.

  • CAS Number: 197366-24-8
  • MF: C58H62N24Na2O22S6
  • MW: 1685.62
  • Catalog: RSV
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

RD3-0028

RD3-0028 is a potent and selective inhibitor of RSV replication with an EC50 of 4.5 μM.

  • CAS Number: 3886-39-3
  • MF: C8H8S2
  • MW: 168.27900
  • Catalog: RSV
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Roflumilast-d4

Roflumilast-d4 is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells[1][2].

  • CAS Number: 1398065-69-4
  • MF: C17H10D4Cl2F2N2O3
  • MW: 407.23
  • Catalog: RSV
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

RSV L-protein-IN-3

RSV L-protein-IN-3 is a wild-type RSV polymerase inhibitor with an IC50 value of 10.4 μM and an EC50 value of 2.1 μM (against RSV). RSV L-protein-IN-3 has lesser cytotoxicity than the clinical agent, Ribavirin (HY-B0434)[1].

  • CAS Number: 868860-35-9
  • MF: C31H34N4O4
  • MW: 526.63
  • Catalog: RSV
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

RSV-IN-7

RSV-IN-7 (example 253) is a RSV inhibitor (EC50: < 0.4 μΜ)[1].

  • CAS Number: 2070852-76-3
  • MF: C27H22F3N7O3
  • MW: 549.50
  • Catalog: RSV
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Ac-CoA Synthase Inhibitor1

Ac-CoA Synthase Inhibitor1 is an anti-virus agent.

  • CAS Number: 508186-14-9
  • MF: C20H18N4O2S2
  • MW: 410.513
  • Catalog: RSV
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 539.3±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 280.0±30.1 °C