4'-C-Fluoro-uridine
Modify Date: 2024-01-11 18:18:30
4'-C-Fluoro-uridine structure
|
Common Name | 4'-C-Fluoro-uridine | ||
|---|---|---|---|---|
| CAS Number | 1613589-24-4 | Molecular Weight | 262.19 | |
| Density | 1.77±0.1 g/cm3(Predicted) | Boiling Point | N/A | |
| Molecular Formula | C9H11FN2O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 4'-C-Fluoro-uridineEIDD-2749 (4'-Fluorouridine) is an orally active, low cytotoxic and broad-spectrum mononegavirus inhibitor (SI≥1877). EIDD-2749 effectively blocks the replication of respiratory syncytial virus (RSV) and SARS-CoV-2. EIDD-2749 can be used in the study of RSV, SARSCoV-2 and related RNA virus infections[1]. |
| Name | 4'-C-Fluoro-uridine |
|---|
| Description | EIDD-2749 (4'-Fluorouridine) is an orally active, low cytotoxic and broad-spectrum mononegavirus inhibitor (SI≥1877). EIDD-2749 effectively blocks the replication of respiratory syncytial virus (RSV) and SARS-CoV-2. EIDD-2749 can be used in the study of RSV, SARSCoV-2 and related RNA virus infections[1]. |
|---|---|
| Related Catalog | |
| Target |
RSV,SARSCoV-2[1]. |
| In Vitro | EIDD-2749 induces a delayed stalling of phosphodiester bond formation by RSV and SARS-CoV-2 RdRP[1]. EIDD-2749 is rapidly anabolizes, metabolically stable, and potently antiviral in disease-relevant well-differentiated HAE cultures[1]. |
| In Vivo | EIDD-2749 (0.2, 1, 5 mg/kg; p.o.; single daily for 4 days) shows good orally efficacious in RSV infection mice model in a dose-dependent manner[1]. Animal Model: Balb/cJ mice (RSV infection model)[1]. Dosage: 0.2, 1, 5 mg/kg Administration: Oral administration; single daily for 4 days Result: Resulted in a statistically significant reduction in lung virus load. |
| Density | 1.77±0.1 g/cm3(Predicted) |
|---|---|
| Molecular Formula | C9H11FN2O6 |
| Molecular Weight | 262.19 |