3411-37-8

3411-37-8 structure

Name: Sophoranol
Chemical Name: (+)-sophoranol
CAS Number: 3411-37-8
Molecular Formula: C₁₅H₂₄N₂O₂
Molecular Weight: 264.36300
Catalog: Signaling Pathways Anti-infection HBV
Create Date: 2016-05-06 01:46:06
Modify Date: 2025-08-26 09:10:32
Sophoranol is an alkaloid that can be isolated from S. flavescens, with antiviral activity. Sophoranol has anti-HBV (hepatitis B virus) activity. Sophoranol shows potent antiviral activities against respiratory syncytial virus (RSV) with an IC50 of 10.4 μg/mL[1][2].

Name	(+)-sophoranol
Synonyms	(+)-5-hydroxymatrine 5-Hydroxy-matrin sophoranol 5-hydroxy-matridin-15-one 5-Hydroxy-matridin-15-on Sophoranol

Description	Sophoranol is an alkaloid that can be isolated from S. flavescens, with antiviral activity. Sophoranol has anti-HBV (hepatitis B virus) activity. Sophoranol shows potent antiviral activities against respiratory syncytial virus (RSV) with an IC50 of 10.4 μg/mL[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV Signaling Pathways >> Anti-infection >> RSV
Target	IC50: 10.4 μg/mL (RSV)[2]
In Vitro	Sophoranol has a remarkable inhibitory effect on the secretion of HBsAg and HBeAg n in the 2.2.15 cell line[1].
References	[1]. Guan Ye, et al. LC-MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts. Biomed Chromatogr. 2007 Jun;21(6):655-60. [2]. Shuang-Cheng Ma, et al. Antiviral Chinese medicinal herbs against respiratory syncytial virus. J Ethnopharmacol. 2002 Feb;79(2):205-11.