ATM/ATR are members of the PI3 family of serine-threonine kinases and function as essential links between the sensors and effectors of the DNA damage response. The roles of ATM and ATR partially overlap and are cooperative; however they are also known to play distinct roles in protecting the cell from DNA damage. ATM is mostly responsible for sending signals from DSBs (double-strand breaks) induced by ionizing radiation while the closely related ATR responds to UV damage or stalled replication forks. ATM and ATR are known to phosphorylate common as well as specific substrates to activate checkpoint signaling. The G1, S, and G2 cell cycle checkpoints are primarily regulated by the ATM (ataxia telangiectasia, mutated) and ATR (ATM and Rad3-related) protein kinases.


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Mirin

Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC50=12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells[1].

  • CAS Number: 299953-00-7
  • MF: C10H8N2O2S
  • MW: 220.248
  • Catalog: ATM/ATR
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 441.6±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 220.8±31.5 °C

ATM Inhibitor-6

ATM inhibitor-6 (A-193) is a selective ATM kinase inhibitor. ATM inhibitor-6 can be used in cancer research[1].

  • CAS Number: 2765544-85-0
  • MF: C28H33FN6O2
  • MW: 504.60
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

ATR inhibitor 1

ATR inhibitor 1 is a ATR inhibitor extracted from patent WO2015187451A1, compound I-l, has a Ki value below 1 µΜ[1].

  • CAS Number: 1613200-51-3
  • MF: C16H12F2N8O
  • MW: 370.32
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

ATM-IN-1

ATM-IN-1 is a potent inhibitor of ATM. ATM is located mainly in the nucleus and microsomes and is involved in cell cycle progression and in the cell cycle checkpoint response to DNA damage. ATM-IN-1 has the potential for the research of cancer and neurology diseases (extracted from patent WO2021139814A1, compound 3)[1].

  • CAS Number: 2662761-76-2
  • MF: C30H36N6O3
  • MW: 528.65
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

SKLB-197

SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.

  • CAS Number: 2713577-16-1
  • MF: C25H24N6O
  • MW: 424.50
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Garcinone C

Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia Champ that is used as an anti-inflammatory, analgesia, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, while efficiently inhibiting the expression levels of cyclin B1, cyclin D1, cyclin E2, cdc2, Stat3 and CDK7. Garcinone C significantly inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner[1].

  • CAS Number: 76996-27-5
  • MF: C23H26O7
  • MW: 414.448
  • Catalog: ATM/ATR
  • Density: 1.367
  • Boiling Point: 689.0±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 239.7±25.0 °C

ATR-IN-6

ATR-IN-6 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-6 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent WO2021233376A1, compound A22)[1].

  • CAS Number: 2746446-99-9
  • MF: C28H28FN7O2
  • MW: 513.57
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Berzosertib (VE-822)

Berzosertib (VE-822) is an ATR inhibitor with a Ki value of less than 0.2 nM. It also inhibits ATM with a Ki of 34 nM.

  • CAS Number: 1232416-25-9
  • MF: C24H25N5O3S
  • MW: 463.552
  • Catalog: ATM/ATR
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 674.4±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 361.7±31.5 °C

Wortmannin

Wortmannin is a multi-target inhibitor of PI3K and MLCK with IC50s of 3 nM and 200 nM, respectively. Wortmannin is also a potent inhibitor of DNA-PK (IC50, 16 nM) and ATM (IC50, 150 nM). Wortmannin is also a potent inhibitor of Polo-like kinase (Plk).

  • CAS Number: 19545-26-7
  • MF: C23H24O8
  • MW: 428.432
  • Catalog: ATM/ATR
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 615.6±55.0 °C at 760 mmHg
  • Melting Point: 234-240ºC
  • Flash Point: 326.1±31.5 °C

(S)-Ceralasertib

(S)-Ceralasertib is extracted from patent WO2011154737A1, Compound II, exhibits an IC50 of 2.578 nM[1].(S)-Ceralasertib is a potent and selective sulfoximine morpholinopyrimidine ATR inhibitor with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics.(S)-Ceralasertib is developed improving aqueous solubility and eliminates CYP3A4 time-dependent inhibition[2].

  • CAS Number: 1352226-87-9
  • MF: C20H24N6O2S
  • MW: 412.51
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

VX-803 (M4344)

ATR inhibitor 2 is an ATP-competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity[1][2].

  • CAS Number: 1613191-99-3
  • MF: C25H29F2N9O3
  • MW: 541.55
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

ATR-IN-4

ATR-IN-4 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13)[1].

  • CAS Number: 2574545-45-0
  • MF: C18H20N8O
  • MW: 364.40
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

ATR-IN-5

ATR-IN-5 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-5 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent CN112047938A, compound D24)[1].

  • CAS Number: 2601571-19-9
  • MF: C27H32F3N9O
  • MW: 555.60
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Ceralasertib(AZD6738)

AZD6738 is a potent inhibitor of ATR kinase with an IC50 of 1 nM.

  • CAS Number: 1352226-88-0
  • MF: C20H24N6O2S
  • MW: 412.509
  • Catalog: ATM/ATR
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

NU6027

NU6027 is a potent and ATP-competitive inhibitor of both CDK1 and CDK2, with Kis of 2.5 µM and 1.3 µM, respectively. NU6027 is also a potent inhibitor of ATR and enhances hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner[1][2].

  • CAS Number: 220036-08-8
  • MF: C11H17N5O2
  • MW: 251.285
  • Catalog: ATM/ATR
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 549.2±60.0 °C at 760 mmHg
  • Melting Point: 252.5-253.7 °C(lit.)
  • Flash Point: 286.0±32.9 °C

M4076

M4076 is a higly potent, selective, ATP-competitive inhibitor of ATM kinase with IC50 of 0.2 nM.M4076 sensitizes tumor cell lines to radiation therapy in vitro and strongly enhances the anti-tumor activity of ionizing radiation in vivo.

  • CAS Number: 2020089-41-0
  • MF: C23H21FN6O3
  • MW: 448.458
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

KU 60019

KU-60019 is an improved ATM kinase-specific inhibitor with IC50 of 6.3 nM.

  • CAS Number: 925701-46-8
  • MF: C30H33N3O5S
  • MW: 547.665
  • Catalog: ATM/ATR
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 786.6±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 429.5±32.9 °C

ATR-IN-15

ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC50 of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K, with IC50 values of 47, 663 and 5131 nM, respectively[1].

  • CAS Number: 2756665-52-6
  • MF: C19H22N8O
  • MW: 378.43
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

ATR-IN-14

ATR-IN-14 (compound 1) is a potent ATR kinase inhibitor. ATR-IN-14 inhibits ATR signaling pathways downstream CHKI protein phosphorylation, with inhibition of 98.03% at 25 nM. ATR-IN-14 shows good anticancer activity in LoVo cells, with an IC50 of 64 nM[1].

  • CAS Number: 2765785-88-2
  • MF: C20H20FN7O
  • MW: 393.42
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

AZ20

AZ20 is a potent and selective inhibitor of ATR with an IC50 of 5 nM, and has 8-fold selectivity against mTOR (IC50=38 nM).

  • CAS Number: 1233339-22-4
  • MF: C21H24N4O3S
  • MW: 412.505
  • Catalog: ATM/ATR
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 634.6±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 337.6±31.5 °C

ATM Inhibitor-5

ATM Inhibitor-5 [formula (1)] is a potent inhibitor of serine/threonine protein kinase ATM (extracted from patent WO2022058351A1)[1].

  • CAS Number: 2495096-26-7
  • MF: C23H21FN6O3
  • MW: 448.45
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

VE-821

VE-821 is a potent ATP-competitive inhibitor of ATR with Ki/IC50 of 13 nM/26 nM.

  • CAS Number: 1232410-49-9
  • MF: C18H16N4O3S
  • MW: 368.410
  • Catalog: ATM/ATR
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 568.4±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 297.6±30.1 °C

ATR-IN-19

ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor[1].

  • CAS Number: 2648989-61-9
  • MF: C18H19N7OS
  • MW: 381.45
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

KU 59403

KU 59403 is a potent ATM inhibitor, with an IC50 of 3 nM.

  • CAS Number: 845932-30-1
  • MF: C29H32N4O4S2
  • MW: 564.719
  • Catalog: ATM/ATR
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 814.3±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 446.3±34.3 °C

Elimusertib (BAY-1895344) hydrochloride

BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity[1].

  • CAS Number: 1876467-74-1
  • MF: C20H22ClN7O
  • MW: 411.89
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Camonsertib

ATR inhibitor 4 (compound 121) is a potent ATR inhibitor. ATR inhibitor 4 has antitumor activity[1].

  • CAS Number: 2417489-10-0
  • MF: C21H26N6O3
  • MW: 410.47
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

ATR-IN-22

ATR-IN-22 (Compound 34) is an orally active ATR inhibitor. ATR-IN-22 inhibits MIAPaCa-2 proliferation (IC50 <1 μM). ATR-IN-22 shows anti-tumor activity in colon cancer[1].

  • CAS Number: 2905312-07-2
  • MF: C25H31N7O
  • MW: 445.56
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

AZD1390

AZD1390 is an ATM inhibitor.

  • CAS Number: 2089288-03-7
  • MF: C27H32FN5O2
  • MW: 477.57
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

ATR-IN-13

ATR-IN-13 (compound A9) is a potent ATR kinase inhibitor, with an IC50 of 2 nM. ATR-IN-13 can be used for ATR kinase mediated diseases research, such as proliferative diseases and cancer[1].

  • CAS Number: 2758113-84-5
  • MF: C24H24FN9O
  • MW: 473.51
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Antitumor agent-28

Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Antitumor agent-28 prevents ATM mediated disease and has potent anti-cancer activity[1].

  • CAS Number: 2097499-67-5
  • MF: C25H32N6O4S
  • MW: 512.62
  • Catalog: ATM/ATR
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A