220036-08-8

220036-08-8 structure

Name: NU6027
Chemical Name: 6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine
CAS Number: 220036-08-8
Molecular Formula: C₁₁H₁₇N₅O₂
Molecular Weight: 251.285
Catalog: Biochemical Inhibitor Cell Cycle CDK inhibitor
Create Date: 2017-05-16 06:42:51
Modify Date: 2025-08-21 13:02:08
NU6027 is a potent and ATP-competitive inhibitor of both CDK1 and CDK2, with Kis of 2.5 µM and 1.3 µM, respectively. NU6027 is also a potent inhibitor of ATR and enhances hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner[1][2].

Name	6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine
Synonyms	6-(Cyclohexylmethoxy)-5-nitroso-2,4-pyrimidinediamine 4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine 2,6-Diamino-4-cyclohexylmethoxy-5-nitroso pyrimidine NU6027 NW1 1e1x 6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE 2,4-Pyrimidinediamine, 6-(cyclohexylmethoxy)-5-nitroso-

Description	NU6027 is a potent and ATP-competitive inhibitor of both CDK1 and CDK2, with Kis of 2.5 µM and 1.3 µM, respectively. NU6027 is also a potent inhibitor of ATR and enhances hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR
Target	CDK1:2.5 μM (Ki) CDK2:1.3 μM (Ki) ATR
In Vitro	NU6027 (1 nM-100 µM; 48 h) inhibits the growth of human tumor cells with a GI50 of 10±6 µM[1]. NU6027 (0.1-25 µM; 24 h) inhibits ATR activity with an IC50 of 2.8 µM in GM847KD cells. NU6027 (1-10 µM; 24 h) inhibits ATR activity with an IC50 of 6.7±2.3 µM in MCF7 cells[2]. NU6027 (4 or 10 µM; 24 h) attenuates G2/M arrest following DNA damage in MCF7 cells[2]. NU6027 (10 µM; 24 h) significantly reduces RAD51 foci in both control and PF-01367338-treated V-C8 B2 cells[2]. NU6027 (4 µM; 24 h) causes 82% suppression of the increase in RAD51 foci-positive cells treated by PF-01367338[2]. Western Blot Analysis[2] Cell Line: MCF7 cells Concentration: 0, 1, 5, 10 μM Incubation Time: 24 h Result: Inhibited CDK2-mediated pRbT821 by 42±27% compared with 70±12% inhibition of pCHK1S345 with the concentration of 10 µM.
References	[1]. Arris CE, et, al. Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. J Med Chem. 2000 Jul 27; 43(15): 2797-804. [2]. Peasland A, et, al. Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines. Br J Cancer. 2011 Jul 26;105(3):372-81.

Density	1.5±0.1 g/cm3
Boiling Point	549.2±60.0 °C at 760 mmHg
Melting Point	252.5-253.7 °C(lit.)
Molecular Formula	C₁₁H₁₇N₅O₂
Molecular Weight	251.285
Flash Point	286.0±32.9 °C
Exact Mass	251.138229
PSA	117.21000
LogP	3.71
Appearance	lavender
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.699
Storage condition	2-8°C
Water Solubility	DMSO: 15 mg/mL

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3

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