SKLB-197

Modify Date: 2024-01-12 10:33:49

SKLB-197 structure	Common Name	SKLB-197
	CAS Number	2713577-16-1	Molecular Weight	424.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₄N₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SKLB-197

SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.

Name	SKLB-197

Description	SKLB-197 showed an IC50 value of 0.013 μM against ATR but very weak or no activity against other 402 protein kinases. It displayed potent antitumor activity against ATM-deficent tumors both in vitro and in vivo.
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR
Target	ATR:0.013 μM (IC50)
References	[1]. Bin H,et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187

Molecular Formula	C₂₅H₂₄N₆O
Molecular Weight	424.50

DC Chemicals Limited
China
Product Name: SKLB-197
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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