2020089-41-0
2020089-41-0 structure
- Name: M4076
- Chemical Name: M4076
- CAS Number: 2020089-41-0
- Molecular Formula: C23H21FN6O3
- Molecular Weight: 448.458
- Catalog: Signaling Pathways Cell Cycle/DNA Damage ATM/ATR
- Create Date: 2022-08-18 07:57:43
- Modify Date: 2023-10-20 14:04:56
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M4076 is a higly potent, selective, ATP-competitive inhibitor of ATM kinase with IC50 of 0.2 nM.M4076 sensitizes tumor cell lines to radiation therapy in vitro and strongly enhances the anti-tumor activity of ionizing radiation in vivo.
| Name | M4076 |
|---|
| Description | M4076 is a higly potent, selective, ATP-competitive inhibitor of ATM kinase with IC50 of 0.2 nM.M4076 sensitizes tumor cell lines to radiation therapy in vitro and strongly enhances the anti-tumor activity of ionizing radiation in vivo. |
|---|---|
| References | 1. Stakyte K, et al. Nat Struct Mol Biol. 2021 Oct;28(10):789-798. 2. Thomas Fuchss, et al. Cancer Res (2019) 79 (13_Supplement): 3500. |
| Molecular Formula | C23H21FN6O3 |
|---|---|
| Molecular Weight | 448.458 |