2574545-45-0

2574545-45-0 structure

Name: ATR-IN-4
Chemical Name: ATR-IN-4
CAS Number: 2574545-45-0
Molecular Formula: C₁₈H₂₀N₈O
Molecular Weight: 364.40
Catalog: Signaling Pathways Cell Cycle/DNA Damage ATM/ATR
Create Date: 2022-03-23 19:02:31
Modify Date: 2025-08-27 10:32:44
ATR-IN-4 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13)[1].

Name	ATR-IN-4

Description	ATR-IN-4 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> ATM/ATR Signaling Pathways >> PI3K/Akt/mTOR >> ATM/ATR
References	[1]. Substituted fused heteroaromatic bicyclic compounds as kinase inhibitors and uses thereof. CN112142744A.

Molecular Formula	C₁₈H₂₀N₈O
Molecular Weight	364.40