c-Myc is the master transcription factor for cell proliferation and is involved in numeroushematological and solidcancers. Proto-oncogene c-Myc, encoding one of the most important transcription factors, plays a pivotal role in tumor initiation and progression. c-Myc regulates hundreds of disparate target genes that participate numerous biological effects, such as cell proliferation, apoptosis, differentiation, and stem cell self-renewal. c-Myc is one of the four factors used in reprogramming somatic cells to induce pluripotent stem (iPS) cells and is implicated in maintaining cancer stem-like cells (CSCs). The transcription factor c-Myc is a key mediator of the Notch signaling–regulated T cell differentiation. In a well-established in vitro differentiation model of T lymphocytes from hematopoietic stem cells, Notch1 and 4 directly promotes c-Myc expression; dominant-negative (DN) c-Myc inhibits early T cell differentiation. Moreover, the c-Myc expression activated by Notch signaling increases the expression of survivin, an inhibitor of apoptosis (IAP) protein. c-Myc gene, as a transcription factor of hTERT, is over expressed in a variety of tumors.c-Myc and hTERT expression in local recurrent gastric cancer tissues is much higher than in primary gastric cancer tissues at the protein and mRNA levels.


Anti-infection >
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Antibody-drug Conjugate >
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Apoptosis >
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Autophagy >
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JAK/STAT Signaling >
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MAPK/ERK Pathway >
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Membrane Transporter/Ion Channel >
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Metabolic Enzyme/Protease >
15-PGDH 5 alpha Reductase 5-Lipoxygenase Acetyl-CoA Carboxylase Acyltransferase Adenosine Deaminase Adenosine Kinase Aldehyde Dehydrogenase (ALDH) Aldose Reductase Aminopeptidase Angiotensin-converting Enzyme (ACE) ATGL ATP Citrate Lyase Carbonic Anhydrase Carboxypeptidase Cathepsin CETP COMT Cytochrome P450 Dipeptidyl Peptidase Dopamine β-hydroxylase E1/E2/E3 Enzyme Elastase Enolase FAAH FABP Factor Xa Farnesyl Transferase Fatty Acid Synthase (FAS) FXR Glucokinase GSNOR Gutathione S-transferase HCV Protease Hexokinase HIF/HIF Prolyl-Hydroxylase HIV Integrase HIV Protease HMG-CoA Reductase (HMGCR) HSP Indoleamine 2,3-Dioxygenase (IDO) Isocitrate Dehydrogenase (IDH) Lactate Dehydrogenase LXR MAGL Mineralocorticoid Receptor Mitochondrial Metabolism MMP Nampt NEDD8-activating Enzyme Neprilysin PAI-1 PDHK PGC-1α Phosphatase Phosphodiesterase (PDE) Phospholipase Procollagen C Proteinase Proteasome Pyruvate Kinase RAR/RXR Renin ROR Ser/Thr Protease SGK Stearoyl-CoA Desaturase (SCD) Thrombin Tryptophan Hydroxylase Tyrosinase Xanthine Oxidase
Neuronal Signaling >
5-HT Receptor AChE Adenosine Kinase Amyloid-β Beta-secretase CaMK CGRP Receptor COMT Dopamine Receptor Dopamine Transporter FAAH GABA Receptor GlyT iGluR Imidazoline Receptor mAChR Melatonin Receptor Monoamine Oxidase nAChR Neurokinin Receptor Opioid Receptor Serotonin Transporter γ-secretase
NF-κB >
NF-κB IKK Keap1-Nrf2 MALT1
PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
Ack1 ALK Bcr-Abl BMX Kinase Btk c-Fms c-Kit c-Met/HGFR Discoidin Domain Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 IGF-1R Insulin Receptor IRAK Itk PDGFR PKA Pyk2 ROS Src Syk TAM Receptor Trk Receptor VEGFR
Stem Cell/Wnt >
Casein Kinase ERK Gli GSK-3 Hedgehog Hippo (MST) JAK Notch Oct3/4 PKA Porcupine ROCK sFRP-1 Smo STAT TGF-beta/Smad Wnt YAP β-catenin γ-secretase
TGF-beta/Smad >
TGF-beta/Smad PKC ROCK TGF-β Receptor
Vitamin D Related >
VD/VDR
Others >
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BRD4 Inhibitor-18

BRD4 Inhibitor-18 is a highly potent BRD4 inhibitor with IC50 value of 110 nM. BRD4 Inhibitor-18 has a hydrophobic acetylcyclopentanyl side chain. BRD4 Inhibitor-18 can significantly suppress the proliferation of MV-4-11 cells with high BRD4 level. BRD4 Inhibitor-18 has apoptosis-promoting and G0/G1 cycle-arresting activity[1].

  • CAS Number: 2451219-73-9
  • MF: C26H26ClN3O3S
  • MW: 496.02
  • Catalog: Apoptosis
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

MYCi361

MYCi361 (NUCC-0196361) is a MYC inhibitor with the Kd of 3.2 μM for binding to MYC. MYCi361 (NUCC-0196361) suppresses tumor growth and enhances anti-PD1 immunotherapy[1].

  • CAS Number: 2289690-31-7
  • MF: C26H16ClF9N2O2
  • MW: 594.86
  • Catalog: c-Myc
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

8α-Tigloyloxyhirsutinolide 13-O-acetate

8α-Tigloyloxyhirsutinolide 13-O-acetate is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and Pyroptosis, and late DNA damage, cell cycle arrest, Apoptosis in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo[1][2].

  • CAS Number: 83182-58-5
  • MF: C22H28O8
  • MW: 420.453
  • Catalog: Apoptosis
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 589.6±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 201.4±23.6 °C

ML327

ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).

  • CAS Number: 1883510-31-3
  • MF: C19H18N4O4
  • MW: 366.37
  • Catalog: c-Myc
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

NY2267

NY2267 is a disruptor of Myc-Max interaction, with an IC50 of 36.5 μM. NY2267 inhibits Myc- and Jun-induced transcriptional activation[1].

  • CAS Number: 886053-73-2
  • MF: C38H43N3O6
  • MW: 637.76
  • Catalog: c-Myc
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

m-Se3

m-Se3 is a potent and selective c-MYC transcription inhibitor that can inhibit tumor growth and has anti-cancer activity[1].

  • CAS Number: 2829939-44-6
  • MF: C29H23IN2Se
  • MW: 605.37
  • Catalog: c-Myc
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

PROTAC BRD4 Degrader-6

PROTAC BRD4 Degrader-6 (compound 32a) is a potent small-molecule BRD4 degrader with IC50 value of 2.7 nM for BRD4 BD1. PROTAC BRD4 Degrader-6 potently degrades BRD4 protein and inhibits the expression of c-Myc. PROTAC BRD4 Degrader-6 inhibits the proliferation of pancreatic cancer cell line BxPC3 and induces apoptosis. PROTAC BRD4 Degrader-6 can be used for human pancreatic cancer research[1].

  • CAS Number: 2410947-56-5
  • MF: C43H40F2N10O10S
  • MW: 926.90
  • Catalog: Apoptosis
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

MYC-IN-2

MYC-IN-2 is a MYC protein-protein inhibitor. MYC-IN-2 can be used for the research of cancer[1].

  • CAS Number: 2244979-61-9
  • MF: C25H17N3O2S
  • MW: 423.49
  • Catalog: c-Myc
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Stauprimide

Stauprimide is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation. Stauprimide is a non-broad spectrum inhibitor that binds to the MYC transcription factor NME2 and blocks its nuclear localization in ESCs, which results in down-regulation of MYC transcription[1].

  • CAS Number: 154589-96-5
  • MF: C35H28N4O5
  • MW: 584.621
  • Catalog: c-Myc
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: 145°C
  • Flash Point: N/A

Chrysomycin A

Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway[1].

  • CAS Number: 82196-88-1
  • MF: C28H28O9
  • MW: 508.517
  • Catalog: Bacterial
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 799.7±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 269.6±26.4 °C

Idarubicin

Idarubicin is an orally active and potent anthracycline antileukemic agent. Idarubicin inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin shows induction of DNA damage. Idarubicin inhibits DNA synthesis and of c-myc expression. Idarubicin inhibits the growth of bacteria and yeasts[1][2][3][4][5].

  • CAS Number: 58957-92-9
  • MF: C26H27NO9
  • MW: 497.494
  • Catalog: Bacterial
  • Density: 1.6±0.1 g/cm3
  • Boiling Point: 725.4±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 392.5±32.9 °C

3-(3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)thiazolidine-2,4-dione

10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects[1][2].

  • CAS Number: 312631-87-1
  • MF: C18H14Cl2N2O3S
  • MW: 409.28600
  • Catalog: c-Myc
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Mycro 3

Mycro 3 is potent and selective for c-Myc in whole cell assays.

  • CAS Number: 944547-46-0
  • MF: C24H17ClF2N6O4
  • MW: 526.879
  • Catalog: c-Myc
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

KJ Pyr 9

KJ Pyr 9 is an inhibitor of MYC with a Kd of 6.5 nM in in vitro assay.

  • CAS Number: 581073-80-5
  • MF: C22H15N3O4
  • MW: 385.372
  • Catalog: c-Myc
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 584.4±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 307.2±30.1 °C

c-Myc inhibitor 9

c-Myc inhibitor 9 (compound 332) is a c-Myc inhibitor with an logEC50 of ≥6. c-Myc inhibitor 9 inhibits tumor growth in nude mouse models. c-Myc inhibitor 9 can be used for cancer research[1].

  • CAS Number: 2799717-96-5
  • MF: C27H31N5OS
  • MW: 473.63
  • Catalog: c-Myc
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

VPC-70063

VPC-70063 is a potent Myc-Max inhibitor with an IC50 value of 8.9 μM for Myc-Max transcriptional activity inhibition. VPC-70063 reduces UBE2C promotor activity and AR-V7 levels, and induces PARP cleavage. VPC-70063 induces apoptosis and blocks Myc-Max interactions with DNA. VPC-70063 can be used for researching anticancer[1].

  • CAS Number: 13571-44-3
  • MF: C16H12F6N2S
  • MW: 378.34
  • Catalog: Apoptosis
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Anticancer agent 84

Anticancer agent 84 is an anticancer agent. Anticancer agent 84 represses the transcription of c-MYC by stabilizing the G-quadruplex (G4) structure. Anticancer agent 84 can be used for the research of cancer[1].

  • CAS Number: 2714510-72-0
  • MF: C57H67N7O9
  • MW: 994.18
  • Catalog: c-Myc
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

KSI-3716

KSI-3716 is a c-Myc inhibitor.

  • CAS Number: 1151813-61-4
  • MF: C17H11BrCl2N2O2
  • MW: 426.09
  • Catalog: c-Myc
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

c-Myc inhibitor 7

c-Myc inhibitor 7 is a c-Myc inhibitor and a multiple target protein degrader. c-Myc inhibitor 7 effective degrades c-MYC, CK1α, GSPT1 and IKZF1/2/3 proteins in a variety of tumor cells. c-Myc inhibitor 7 can be used for c-Myc high expression related disease research, such as cancer, cardiovascular and cerebrovascular diseases, and viral infection[1].

  • CAS Number: 2883535-99-5
  • MF: C35H30N6O5
  • MW: 614.65
  • Catalog: c-Myc
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Anticancer agent 76

Anticancer agent 76 (Compound CT2-3) is an anticancer agent. Anticancer agent 76 significantly inhibits the proliferation of human NSCLC cells, induces cell cycle arrest, causes ROS generation and induces cell apoptosis[1].

  • CAS Number: 2448091-11-8
  • MF: C32H33NO5S
  • MW: 543.67
  • Catalog: Apoptosis
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

MYCi975

MYCi975 (NUCC-0200975) is an orally active MYC inhibitor, which disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 (NUCC-0200975) exhibits potent anti-tumor efficacy with good tolerability, increases tumor immune cell infiltration, and sensitizes tumors to anti-PD1 immunotherapy[1].

  • CAS Number: 2289691-01-4
  • MF: C25H16Cl2F6N2O2
  • MW: 561.30
  • Catalog: c-Myc
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

LFS-1107

LFS-1107 is a reversible CRM1 inhibitor (Kd: 12.5 pM). LFS-1107 can selectively eliminate extranodal natural killer/T cell lymphoma (ENKTL) cells and can be used for cancer research[1].

  • CAS Number: 1799330-91-8
  • MF: C12H11N5OS2
  • MW: 305.38
  • Catalog: c-Myc
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

10058-F4

10058-F4 is a c-Myc inhibitor that prevents c-Myc-Max dimerization and transactivation of c-Myc target gene expression.

  • CAS Number: 403811-55-2
  • MF: C12H11NOS2
  • MW: 249.352
  • Catalog: c-Myc
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 387.1±52.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 187.9±30.7 °C

IZTZ-1

IZTZ-1, an imidazole-benzothiazole conjugate, is a c-MYC G4 ligand. IZTZ-1 is able to downregulate the c-MYC expression by stabilizing c-MYC G4. IZTZ-1 induces cell cycle arrest, apoptosis, thereby inhibiting cell proliferation in B16 cells. IZTZ-1 shows antitumor activity, and can be used for melanoma research[1].

  • CAS Number: 2636771-45-2
  • MF: C32H35N7S
  • MW: 549.73
  • Catalog: Apoptosis
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

IRES-C11

A novel, spectfic c-Myc IRES (internal ribosome entry site) function inhibitor that prevents binding of hnRNP A1 to the Myc IRES and specifically inhibits Myc IRES activity in MM cells; shows no effect on BAG-1, XIAP and p53 IRESes, and has no significant effect on myc translation; significantly inhibits myc expression when combined with ER stress inducers, especially bortezomib; shows synergistic anti-MM cytotoxicity combined with ER stress inducers; also blocks cyclin D1 IRES-dependent initiation and demonstrates synergistic anti-GBM properties combined with PP242.

  • CAS Number: 342416-30-2
  • MF: C13H11Cl2NO4
  • MW: 316.137
  • Catalog: c-Myc
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 415.8±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 205.3±28.7 °C

c-Myc inhibitor 6

c-Myc inhibitor 6 (compound A102) is a c-Myc inhibitor. c-Myc inhibitor 6 decreases cancer cell viability and degrades c-Myc protein. c-Myc inhibitor 6 can be used for the research of c-Myc imbalance, such as cancer, cardiovascular diseases, and viral infection[1].

  • CAS Number: 2768765-58-6
  • MF: C23H29BN2O5
  • MW: 424.30
  • Catalog: c-Myc
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Bouvardin,5-(N-methyl-L-tyrosine)- (9CI)

RA-V is a cyclic hexapeptide. RA-V has activity against Wnt, Myc and Notch with IC50 values of 50, 75, and 93 ng/mL, respectively. RA-V can be used for the research of cancer-related signaling pathways.

  • CAS Number: 64725-24-2
  • MF: C40H48N6O9
  • MW: 756.84400
  • Catalog: c-Myc
  • Density: 1.189g/cm3
  • Boiling Point: 1083.3ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 609ºC

IZCZ-3

IZCZ-3 is a potent c-MYC transcription inhibitor with antitumor activity.

  • CAS Number: 2223019-53-0
  • MF: C46H49N7O
  • MW: 715.93
  • Catalog: c-Myc
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

10074-G5

10074-G5 is an inhibitor of c-Myc-Max dimerization with an IC50 of 146 μM.

  • CAS Number: 413611-93-5
  • MF: C18H12N4O3
  • MW: 332.313
  • Catalog: c-Myc
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 538.6±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 279.5±32.9 °C

c-Myc inhibitor 8

c-Myc inhibitor 8 (compound 56) is a c-Myc inhibitor. c-Myc inhibitor 8 effectively inhibits cell viability of a variety of cancer cells. c-Myc inhibitor 8 inhibits human prostate and lung cancer growth in mouse models. c-Myc inhibitor 8 can be used for cancer research[1].

  • CAS Number: 2173505-97-8
  • MF: C19H12BrClF3NO3S2
  • MW: 538.79
  • Catalog: c-Myc
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A