Anticancer agent 76
Modify Date: 2024-01-12 17:42:56
Anticancer agent 76 structure
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Common Name | Anticancer agent 76 | ||
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| CAS Number | 2448091-11-8 | Molecular Weight | 543.67 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H33NO5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Anticancer agent 76Anticancer agent 76 (Compound CT2-3) is an anticancer agent. Anticancer agent 76 significantly inhibits the proliferation of human NSCLC cells, induces cell cycle arrest, causes ROS generation and induces cell apoptosis[1]. |
| Name | Anticancer agent 76 |
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| Description | Anticancer agent 76 (Compound CT2-3) is an anticancer agent. Anticancer agent 76 significantly inhibits the proliferation of human NSCLC cells, induces cell cycle arrest, causes ROS generation and induces cell apoptosis[1]. |
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| Related Catalog | |
| In Vitro | Anticancer agent 76 (Compound CT2-3) (0-80 μM, 24 h) inhibits the proliferation of human NSCLC cells[1]. Anticancer agent 76 (40 μM, 24 h) arrests cell cycle at G1 phase, induces apoptosis and ROS, suppresses the expression of c-Myc and topoisomerases in NSCLC cells [1]. Cell Proliferation Assay[1] Cell Line: A549 and H460 Concentration: 0, 10, 20, 40, 60 and 80 μM Incubation Time: 24 h Result: Inhibited the proliferation with IC50 values of 41.63 μM and 38.03 μM against A549 and H460 cells, respectively. Cell Cycle Analysis[1] Cell Line: H460 Concentration: 40 μM Incubation Time: 24 h Result: Resulted in increasing cell populations at the G1 phase, down-regulated CDK4, CDK6 and cyclin D1. Apoptosis Analysis[1] Cell Line: A549 and H460 Concentration: 20 μM and 40 μM Incubation Time: 24 h Result: Induced apoptosis. Western Blot Analysis[1] Cell Line: H460 cell Concentration: 40 μM Incubation Time: 24 h Result: Down-regulated mRNA of TOP2B, TOP3B and c-Myc. |
| References |
| Molecular Formula | C32H33NO5S |
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| Molecular Weight | 543.67 |