2448091-11-8
2448091-11-8 structure
- Name: Anticancer agent 76
- Chemical Name: Anticancer agent 76
- CAS Number: 2448091-11-8
- Molecular Formula: C32H33NO5S
- Molecular Weight: 543.67
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2022-09-01 06:06:59
- Modify Date: 2024-01-12 17:42:56
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Anticancer agent 76 (Compound CT2-3) is an anticancer agent. Anticancer agent 76 significantly inhibits the proliferation of human NSCLC cells, induces cell cycle arrest, causes ROS generation and induces cell apoptosis[1].
| Name | Anticancer agent 76 |
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| Description | Anticancer agent 76 (Compound CT2-3) is an anticancer agent. Anticancer agent 76 significantly inhibits the proliferation of human NSCLC cells, induces cell cycle arrest, causes ROS generation and induces cell apoptosis[1]. |
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| Related Catalog | |
| In Vitro | Anticancer agent 76 (Compound CT2-3) (0-80 μM, 24 h) inhibits the proliferation of human NSCLC cells[1]. Anticancer agent 76 (40 μM, 24 h) arrests cell cycle at G1 phase, induces apoptosis and ROS, suppresses the expression of c-Myc and topoisomerases in NSCLC cells [1]. Cell Proliferation Assay[1] Cell Line: A549 and H460 Concentration: 0, 10, 20, 40, 60 and 80 μM Incubation Time: 24 h Result: Inhibited the proliferation with IC50 values of 41.63 μM and 38.03 μM against A549 and H460 cells, respectively. Cell Cycle Analysis[1] Cell Line: H460 Concentration: 40 μM Incubation Time: 24 h Result: Resulted in increasing cell populations at the G1 phase, down-regulated CDK4, CDK6 and cyclin D1. Apoptosis Analysis[1] Cell Line: A549 and H460 Concentration: 20 μM and 40 μM Incubation Time: 24 h Result: Induced apoptosis. Western Blot Analysis[1] Cell Line: H460 cell Concentration: 40 μM Incubation Time: 24 h Result: Down-regulated mRNA of TOP2B, TOP3B and c-Myc. |
| References |
| Molecular Formula | C32H33NO5S |
|---|---|
| Molecular Weight | 543.67 |