1242862-71-0

1242862-71-0 structure
1242862-71-0 structure
  • Name: FUBP1-IN-2
  • Chemical Name: FUBP1-IN-2
  • CAS Number: 1242862-71-0
  • Molecular Formula: C26H26ClN3O4
  • Molecular Weight: 479.96
  • Catalog: Signaling Pathways Apoptosis c-Myc
  • Create Date: 2023-01-22 16:42:20
  • Modify Date: 2024-01-11 19:00:45
  • FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines[1].

Name FUBP1-IN-2
Description FUBP1-IN-2 (compound 9) is a potent FUBP1 (far upstream binding protein 1) inhibitor. FUBP1-IN-2 inhibits the KH4 FUBP1-FUSE interaction in a gel shift assay. FUBP1-IN-2 binds to FUBP1 in a ChIP assay. FUBP1-IN-2 reduces both c-Myc mRNA and protein expression, increases p21 mRNA and protein expression, and depletes intracellular polyamines[1].
Related Catalog
In Vitro FUBP1-IN-2 (compound 9) does not inhibit 3 H-spermidine uptake yet works synergistically with Eflornithine (HY-B0744) to limit cell growth in the presence of exogenous spermidine[1].
References

[1]. Dobrovolskaite A, et al. Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 (FUBP1) Function. J Med Chem. 2022 Nov 24;65(22):15391-15415.  

Molecular Formula C26H26ClN3O4
Molecular Weight 479.96