Neprilysin (NEP) is a type II membrane metalloendopeptidase composed of ∼750 residues with an active site containing a zinc-binding motif (HEXXH) at the extracellular carboxyl terminal domain. Neprilysin is capable of degrading the monomeric and the oligomeric forms of Aβ peptide. Neprilysin is the dominant Aβ peptide-degrading enzyme in the brain; Neprilysin becomes inactivated and down-regulated during both the early stages of Alzheimer’s disease (AD) and aging. Neprilysin is a neutral endopeptidase and its inhibition increases bioavailability of natriuretic peptides, bradykinin, and substance P, resulting in natriuretic, vasodilatatory, and anti-proliferative effects.


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Sacubitril/valsartan (LCZ696)

LCZ696 is a dual angiotensin II receptor and neprilysin inhibitor.

  • CAS Number: 936623-90-4
  • MF: C48H60N6Na3O10.5
  • MW: 957.99
  • Catalog: Angiotensin Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

SCH-42354

SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the prodrug SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity[1][2].

  • CAS Number: 144505-58-8
  • MF: C16H23NO3S2
  • MW: 341.49
  • Catalog: Neprilysin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Phosphoramidon disodium salt

Phosphoramidon disodium is a metalloprotease inhibitor. Phosphoramidon inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively.

  • CAS Number: 164204-38-0
  • MF: C23H32N3Na2O10P
  • MW: 587.47
  • Catalog: Angiotensin-converting Enzyme (ACE)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

AHU377-d4

Sacubitril-d4 (AHU-377-d4) is the deuterium labeled Sacubitril. Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril (AHU-377) is a component of the heart failure medicine LCZ696.

  • CAS Number: 1884269-07-1
  • MF: C24H25D4NO5
  • MW: 415.515
  • Catalog: Neprilysin
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 656.9±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 351.1±31.5 °C

AHU-377 hemicalcium salt

Sacubitril (AHU-377) hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696.

  • CAS Number: 1369773-39-6
  • MF: C24H28Ca0.5NO5
  • MW: 430.52
  • Catalog: Neprilysin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

TD-0212 TFA

TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].

  • CAS Number: 1073549-11-7
  • MF: C30H35F4N3O6S
  • MW: 641.67
  • Catalog: Angiotensin Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

NEP-IN-2

NEP-IN-2 is an inhibitor of neutral endopeptidase, used in the research of proliferation in atherosclerosis, restenosis.

  • CAS Number: 145775-14-0
  • MF: C16H23NO3S2
  • MW: 341.48900
  • Catalog: Neprilysin
  • Density: 1.204g/cm3
  • Boiling Point: 603ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 318.5ºC

TD-0212

TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].

  • CAS Number: 1073549-10-6
  • MF: C28H34FN3O4S
  • MW: 527.65
  • Catalog: Angiotensin Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Racecadotril

Racecadotril (acetorphan), a potent enkephalinase inhibitor (IC50= 4.5 uM), protects endogenous enkephalins from degradation. IC50 value: 4.5 uMTarget: EnkephalinaseRacecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 uM. Unlike other medications used to treat diarrhea, which reduce intestinal motility, Racecadotril has an antisecretory effect-it reduces the secretion of water and electrolytes into the intestine. A small randomized controlled trial found Racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy.

  • CAS Number: 81110-73-8
  • MF: C21H23NO4S
  • MW: 385.477
  • Catalog: Neprilysin
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 574.5±50.0 °C at 760 mmHg
  • Melting Point: 89ºC
  • Flash Point: 301.2±30.1 °C

phosphoramidon

Phosphoramidon, a microbial metabolite, is a specific metalloprotease thermolysin inhibitor with an IC50 of 0.4 μg/mL. Phosphoramidon also inhibits endothelin-converting enzyme (ECE), neutral endopeptidase (NEP), and angiotensin-converting enzyme (ACE) with IC50 values of 3.5, 0.034, and 78 μM, respectively[1][2][3].

  • CAS Number: 36357-77-4
  • MF: C23H34N3O10P
  • MW: 543.50400
  • Catalog: Angiotensin-converting Enzyme (ACE)
  • Density: 1.48 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Thiorphan

Thiorphan is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM[1].

  • CAS Number: 76721-89-6
  • MF: C12H15NO3S
  • MW: 253.32
  • Catalog: Neprilysin
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 524.0±50.0 °C at 760 mmHg
  • Melting Point: 138-140ºC
  • Flash Point: 270.7±30.1 °C

Thiorphan-d7

Thiorphan-d7 is the deuterium labeled Thiorphan[1]. Thiorphan is a selective NEP (neprilysin) inhibitor with an IC50 of 6.9 nM[2].

  • CAS Number: 1276297-68-7
  • MF: C12H8D7NO3S
  • MW: 260.361
  • Catalog: Neprilysin
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 524.0±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 270.7±30.1 °C

AHU 377

Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril (AHU-377) is a component of the heart failure medicine LCZ696.

  • CAS Number: 149709-62-6
  • MF: C24H29NO5
  • MW: 411.491
  • Catalog: Neprilysin
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 656.9±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 351.1±31.5 °C

SQ28603

SQ28603 is a potent and selective inhibitor of neutral endopeptidase 3.4.24.11 (NEP), an enzyme that degrades atrial natriuretic peptide (ANP).

  • CAS Number: 100845-83-8
  • MF: C13H17NO3S
  • MW: 267.34400
  • Catalog: Neprilysin
  • Density: 1.216g/cm3
  • Boiling Point: 533.3ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 276.3ºC

Candoxatril

Candoxatril is a neutral endopeptidase (NEP) inhibitor.

  • CAS Number: 123122-55-4
  • MF: C29H41NO7
  • MW: 515.63800
  • Catalog: Neprilysin
  • Density: 1.21g/cm3
  • Boiling Point: 718.4ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 388.3ºC

SCH 42495

SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester prodrug of SCH 42354[1].

  • CAS Number: 136511-43-8
  • MF: C20H29NO4S2
  • MW: 411.57900
  • Catalog: Neprilysin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Sacubitrilat

Sacubitrilat is an active neprilysin (NEP) inhibitor.

  • CAS Number: 149709-44-4
  • MF: C22H25NO5
  • MW: 383.43800
  • Catalog: Neprilysin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Sacubitril sodium

Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19[1][2][3].

  • CAS Number: 149690-05-1
  • MF: C24H28NNaO5
  • MW: 433.47300
  • Catalog: Neprilysin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

NEP-In-1

NEP-IN-1 is a neutral endopeptidase (NEP) inhibitor with IC50 of 2 nM for dNEP.

  • CAS Number: 465527-94-0
  • MF: C21H30ClNO4
  • MW: 395.92
  • Catalog: Neprilysin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Opiorphin trifluoroacetate salt

Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission[1][2].

  • CAS Number: 864084-88-8
  • MF: C29H48N12O8
  • MW: 692.76700
  • Catalog: Neprilysin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Sampatrilat

Sampatrilat (UK-81252) is a potent and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase (NEP). Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM). Sampatrilat (UK-81252) can be used for the study of chronic heart failure and blood pressure regulation[1][2].

  • CAS Number: 129981-36-8
  • MF: C26H40N4O9S
  • MW: 584.68200
  • Catalog: Angiotensin-converting Enzyme (ACE)
  • Density: 1.343g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A