144505-58-8

144505-58-8 structure

Name: SCH-42354
Chemical Name: SCH-42354
CAS Number: 144505-58-8
Molecular Formula: C₁₆H₂₃NO₃S₂
Molecular Weight: 341.49
Catalog: Signaling Pathways Metabolic Enzyme/Protease Neprilysin
Create Date: 2022-08-31 12:16:01
Modify Date: 2024-01-12 22:19:40
SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the prodrug SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity[1][2].

Name	SCH-42354

Description	SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the prodrug SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Neprilysin
In Vitro	SCH-42354 (10-100 nM) increases the potency of natriuretic peptide (ANP) in isolated pulmonary vessels and in isolated perfused whole lungs and increases ANP activity in a dose-dependent manner[1].
References	[1]. Thompson JS, et, al. Neutral endopeptidase inhibition increases the potency of ANP in isolated rat pulmonary resistance vessels and isolated blood perfused lungs. Pulm Pharmacol. 1995 Apr-Jun;8(2-3):143-7. [2]. Watkins RW, et, al. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor. Am J Hypertens. 1993 May;6(5 Pt 1):357-68.

Molecular Formula	C₁₆H₂₃NO₃S₂
Molecular Weight	341.49