DC Chemicals Limited
China
Product Name: TD-0212
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Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1073549-10-6

1073549-10-6 structure

1073549-10-6 structure

Name: TD-0212
Chemical Name: TD-0212
CAS Number: 1073549-10-6
Molecular Formula: C₂₈H₃₄FN₃O₄S
Molecular Weight: 527.65
Catalog: Signaling Pathways GPCR/G Protein Angiotensin Receptor
Create Date: 2019-03-30 12:46:34
Modify Date: 2024-01-11 18:36:46
TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].

Name	TD-0212

Description	TD-0212 (compound 35) is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> Neprilysin
Target	pKi: 8.9 (AT1) pIC50: 9.2 (NEP)[1].
References	[1]. McKinnell RM, et al. Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI). ACS Med Chem Lett. 2018 Dec 3;10(1):86-91.

Molecular Formula	C₂₈H₃₄FN₃O₄S
Molecular Weight	527.65