Opiorphin trifluoroacetate salt
Modify Date: 2024-01-09 01:48:28
Opiorphin trifluoroacetate salt structure
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Common Name | Opiorphin trifluoroacetate salt | ||
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| CAS Number | 864084-88-8 | Molecular Weight | 692.76700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H48N12O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Opiorphin trifluoroacetate saltOpiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission[1][2]. |
| Name | Opiorphin |
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| Synonym | More Synonyms |
| Description | Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission[1][2]. |
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| Related Catalog | |
| In Vitro | Opiorphin (1-100 μM; the mouse isolated colon) causes contractile effects in mouse distal colon in a concentration-dependent manner and enhances the contractile response induced by Met-enkephalin[1]. Opiorphin (0-50 μM; hNEP or hAP-N transformed HEK293 cell line) is a dual inhibitor of enkephalin-degrading hNEP and hAP-N in vitro. Opiorphin inhibits Mca-BK2 endoproteolysis by the cell-surface recombinant hNEP with an IC50 value of 33 μM. and inhibits the Ala-pNA cleavage by hAP-N with an IC50 value of 65 μM[2]. |
| In Vivo | Opiorphin (1.25-10 μg/kg; ICV; 0-60 min; male Kunming mice) induces potent analgesic effect in a dose- and time-dependent manner (ED50=3.22 μg/kg)[1]. Animal Model: Male Kunming mice[1] Dosage: 1.25, 2.5, 5, 10 μg/kg Administration: Intracerebroventrical injection; post-drug latency measurements were performed at 5, 10, 20, 30, 40, 50 and 60 min Result: Had the percentage change of tail withdrawal latency (TWL) at 10 min after i.c.v. administration of 1.25-10 mg/kg was 28.90%, 44.37%, 56.43% and 91.899.79%, respectively. |
| Molecular Formula | C29H48N12O8 |
|---|---|
| Molecular Weight | 692.76700 |
| Exact Mass | 692.37200 |
| PSA | 366.84000 |
| LogP | 0.71060 |
| human opiorphin |
| H-Gln-Arg-Phe-Ser-Arg-OH |
- GL Biochem (Shanghai) Ltd.
- China
- Product Name: Opiorphin
- Price: $Inquiry/1g
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Jackie Yang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Opiorphin
- Price: $Inquiry/1kg
- Purity: 99.0%
- Stocking Period: 1 Day
- Contact: Vinnie
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