Thrombopoietin (TPO) is the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. TPO binds to the thrombopoietin receptor (TPOr, also termed c-mpl) on platelets, megakaryocytes, and pluripotent stem cells leading to inhibition of apoptosis of stem cells and megakaryocytes; increased megakaryocyte number, size, and ploidy; increased rate of megakaryocyte maturation and platelet count; and decreased platelet threshold for activation by ADP and collagen.


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Avatrombopag Maleate

Avatrombopag maleate (AKR-501) is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag maleate mimics the biological activities of TPO. Avatrombopag maleate increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag maleate is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A[1][2][3].

  • CAS Number: 677007-74-8
  • MF: C33H38Cl2N6O7S2
  • MW: 765.72700
  • Catalog: Thrombopoietin Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Lusutrombopag

Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease.

  • CAS Number: 1110766-97-6
  • MF: C29H32Cl2N2O5S
  • MW: 591.546
  • Catalog: Thrombopoietin Receptor
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

TPO agonist 1

TPO agonist 1 can increase production of platelets by stimulating the TPO receptor in people with chronic ITP. (Idiopathic Thrombocytopenic Purpura)target: TPO receptor agonist1、TPO receptor agonists can be also used in Bone marrow fibrosis2、TPOreceptor agonists can decrease bleeding events and reduced need for adjunctive or rescue treatments.

  • CAS Number: 1033040-23-1
  • MF: C25H22N8O2
  • MW: 466.495
  • Catalog: Thrombopoietin Receptor
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 703.5±70.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 379.3±35.7 °C

Rafutrombopag diolamine

Rafutrombopag diolamine is the derivative of Rafutrombopag. Rafutrombopag is a thrombopoietin receptor agonist[1].

  • CAS Number: 1257792-42-9
  • MF: C29H36N6O7
  • MW: 580.63
  • Catalog: Thrombopoietin Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Hetrombopag

Hetrombopag is a potent, selective, orally-active Thrombopoietin (TPO) receptor agonist; specifically stimulates proliferation and/or differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells, with low nanomolar EC50 values through stimulation of STAT, PI3K and ERK signalling pathways; specifically enhances the viability and promoted the growth of 32D-MPL cells in hollow fibres implanted in nude mice, exhibiting much higher potency than eltrombopag in vivo. Other Indication Phase 2 Clinical

  • CAS Number: 2114365-78-3
  • MF: C25H22N4O5
  • MW: 458.474
  • Catalog: Thrombopoietin Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

EltroMbopag Methyl Ester

Eltrombopag methyl ester is a derivative of Eltrombopag, which is a thrombopoietin (Tpo) receptor agonist, which can promote platelet production and is used in research related to specific types of thrombocytopenia[1].

  • CAS Number: 1246929-01-0
  • MF: C26H24N4O4
  • MW: 456.49
  • Catalog: Thrombopoietin Receptor
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 626.5±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 332.7±34.3 °C

Eltrombopag olamine

Eltrombopag is a thrombopoietin-receptor agonist used to treat low blood platelet counts with chronic immune thrombocytopenia.

  • CAS Number: 496775-62-3
  • MF: C29H36N6O6
  • MW: 564.633
  • Catalog: Thrombopoietin Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Eltrombopag

Eltrombopag is a thrombopoietin (TPO) receptor agonist developed for certain conditions that lead to thrombocytopenia.

  • CAS Number: 496775-61-2
  • MF: C25H22N4O4
  • MW: 442.467
  • Catalog: Thrombopoietin Receptor
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 656.8±65.0 °C at 760 mmHg
  • Melting Point: 242-244ºC
  • Flash Point: 351.0±34.3 °C

avatrombopag

Avatrombopag(AKR-501; AS1670542) is a novel orally-active thrombopoietin(TPO) receptor agonist with EC50 of 3.3 nM.EC50 value: 3.3 nM [1]Target: TPO receptor agonistin vitro: AKR-501 specifically targeted the TPO receptor and stimulated megakaryocytopoiesis throughout the development and maturation of megakaryocytes just as rhTPO did. AKR-501, however, was shown to be effective only in humans and chimpanzees with high species specificity [1]. AS1670542 has 50% effective concentration values for cell proliferation with AS1670542 or eltrombopag were 1.9 and 13nM, respectively, while those for megakaryocyte colony formation from human cord blood CD34(+) cells with AS1670542 or eltrombopag were 260 and 950nM, respectively [2].in vivo: Daily oral administration of AKR-501 dose-dependently increased the number of human platelets in in human platelet producing non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice transplanted with human fetal liver CD34(+) cells, with significance achieved at doses of 1 mg/kg and above. The peak unbound plasma concentrations of AKR-501 after administration at 1 mg/kg in NOD/SCID mice were similar to those observed following administration of an active oral dose in human subjects [1]. AS1670542 significantly increased the number of human platelets in non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice with transplanted human hematopoietic stem cells at 0.3 (P<0.05); in contrast, while administration of eltrombopag also increased the numbers of these platelets at 30mg/kg/day (P=0.058), no statistical significance was noted in the increase [2].

  • CAS Number: 570406-98-3
  • MF: C29H34Cl2N6O3S2
  • MW: 649.655
  • Catalog: Thrombopoietin Receptor
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Rafutrombopag

Rafutrombopag is a thrombopoietin (TPO) agonist extracted from patent CN113929668 A.

  • CAS Number: 2600513-51-5
  • MF: C25H22N4O5
  • MW: 458.47
  • Catalog: Thrombopoietin Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Avatrombopag hydrochloride

Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A[1][2][3].

  • CAS Number: 570403-17-7
  • MF: C29H35Cl3N6O3S2
  • MW: 686.12
  • Catalog: Thrombopoietin Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A