Aldehyde dehydrogenase 1 (ALDH1), which is a putative marker of breast cancer stem cells (CSCs), in triple negative breast cancer (TNBC) tissues. Mitochondrial aldehyde dehydrogenase (ALDH2) is a member of the 19-strong human aldehyde dehydrogenase family of NADP+-dependent enzymes. ALDH2, a mitochondrial enzyme responsible for metabolizing the major lipid peroxidation product, protects against acute ischemia/reperfusion injury and chronic heart failure. Activation of ALDH2, the main enzyme that catalyzes 4-HNE metabolism, is sufficient to protect the heart against acute ischemia-reperfusion injury. ALDH2 is a key detoxifying enzyme. ALDH2 is most commonly associated with its role in ethanol metabolism, catalyzing the oxidation of ethanol-derived acetaldehyde to acetate.


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CM121

CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.54 μM;Kd=1.1 μM) with a variety of hydrophobic interactions[1].

  • CAS Number: 2204230-40-8
  • MF: C24H17FN4O3S
  • MW: 460.48
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

ALDH3A1-IN-2

ALDH3A1-IN-2 (Compound 19) is a potent inhibitor of ALDH3A1 with an IC50 of 1.29 μM. Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer. ALDH3A1-IN-2 has the potential for the research of cancer diseases[1].

  • CAS Number: 374635-48-0
  • MF: C11H14N2O3
  • MW: 222.24
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

EN40

ALDH3A1 inhibitor EN40 is a potent and selective, covalent, in vivo-active inhibitor of ALDH3A1 with IC50 of 2 uM, demonstrates no activity against ALDH1A3 and ALDH6A1 at 30 uM; also does not show any observable competition against lysine-reactive probe labeling of A549 proteomes; specifically inhibits the lung cancer cell lines expressing ALDH3A1, but not in the cell lines that do not express ALDH3A1, inhibits ALDH3A1 activity and impairs lung cancer pathogenicity in vivo.

  • CAS Number: 2094547-67-6
  • MF: C13H15NO2
  • MW: 217.268
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

NCT-501

NCT-501 is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM).IC50 value: 40 nMTarget: hALDH1A11) NCT-501 is well absorbed and distributed but rapidly metabolized and/or excreted. NCT-501 does penetrate the blood-brain barrier.2) NCT-501(ALDH1A1 inhibitor) inhibited functional properties, such as self-renewal property, migratory potential and induced sell sensitivity in cisplatin resistant cells. In all, NCT-501 in combination with Cisplatin showed a significant decrease in proliferating cells as compared to individual treatment.You can use NCT-501 (20nM)+ Cisplatin (5 M) to investigate the functional properties.[2]

  • CAS Number: 1802088-50-1
  • MF: C21H32N6O3
  • MW: 416.517
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 627.3±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 333.2±34.3 °C

ALDH1A3-IN-1

ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC50 of 0.63 µM and a Ki of 0.46 µM. ALDH1A3-IN-1 can be studied in prostate cancer[1].

  • CAS Number: 1695970-90-1
  • MF: C13H18BrNO
  • MW: 284.19
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

ALDH3A1-IN-1

ALDH3A1-IN-1 (Compound 18) is a potent inhibitor of ALDH3A1 with an IC50 of 1.61 μM. ALDH3A1-IN-1 is more potent than DEAB against patient-derived primary prostate tumor epithelial cells, as single agents or in combination treatment with docetaxel[1].

  • CAS Number: 1039855-56-5
  • MF: C13H18N2O3
  • MW: 250.29
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

A37

CM037 is a selective inhibitor of ALDH1A1 (aldehyde dehydrogenase 1A1) with an IC50 of 4.6 µM[1].

  • CAS Number: 896795-60-1
  • MF: C21H25N3O3S2
  • MW: 431.572
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Taraxerone

Taraxerone is isolated from Sedum sarmentosum. Taraxerone enhances effects on alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activities with EC50 values of 512.42 and 500.16 μM, respectively[1].

  • CAS Number: 514-07-8
  • MF: C30H48O
  • MW: 424.702
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 488.3±44.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 202.8±23.4 °C

Win 18446

Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes[1][2].

  • CAS Number: 1477-57-2
  • MF: C12H20Cl4N2O2
  • MW: 366.111
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 530.2±50.0 °C at 760 mmHg
  • Melting Point: 118-120ºC
  • Flash Point: 274.5±30.1 °C

ALDH1A1-IN-3

ALDH1A1-IN-3 (compound 57) is an excellent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with an IC50 value of 0.379 μM. ALDH1A1-IN-3 can effectively improve glucose consumption in HepG2 cells. ALDH1A1-IN-3 can be used for researching glucose metabolism improvement[1].

  • CAS Number: 2439177-97-4
  • MF: C31H36F3N5O4
  • MW: 599.64
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

RV01

RV01 is an analogue of resveratrol, inhibits DNA damage, reduces acetaldehyde dehydrogenase 2 (ALDH2) mRNA expression induced by ethanol, and exhibits hydroxyl radical scavenging activity[1]. RV01 decreases iNOS expression, with anti-neuroinflammatory activity[2].

  • CAS Number: 1016897-10-1
  • MF: C17H13NO2
  • MW: 263.29
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Aldehyde dehydrogenase (NAD(P))

Aldehyde dehydrogenase NAD(P) (ALDH) catalyzes the oxidation of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H, is often used in biochemical studies. The aldehyde dehydrogenases (ALDHs) are one of many enzyme systems the body utilizes to alleviate aldehyde stress[1].

  • CAS Number: 9028-88-0
  • MF:
  • MW:
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

YG1702

YG1702 is a potent ALDH18A1-specific inhibitor. YG1702 attenuates the growth of MYCN-amplified NB and down-regulates MYCN. YG1702 physically interacts with ALDH18A1 with a high affinity and might potentially affect its enzymatic activity[1].

  • CAS Number: 724737-08-0
  • MF: C23H30N2O7S
  • MW: 478.56
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

(2E)-4-Hydroxy-2-nonenal

4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].

  • CAS Number: 75899-68-2
  • MF: C9H16O2
  • MW: 156.222
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: 0.9±0.1 g/cm3
  • Boiling Point: 275.6±23.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 115.2±15.2 °C

NCT-501 hydrochloride

NCT-501 hydrochloride is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM)[1][2].

  • CAS Number: 2080306-22-3
  • MF: C21H33ClN6O3
  • MW: 452.98
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

BODIPY aminoacetaldehyde

BODIPY aminoacetaldehyde (BAAA) is a fluorescent substrate for both murine and human aldehyde dehydrogenase (ALDH). BODIPY aminoacetaldehyde consists of an aminoacetaldehyde moiety bonded to the BODIPY fluorochrome and can be used to label stem cells[1].

  • CAS Number: 247069-94-9
  • MF: C16H18BF2N3O2
  • MW: 333.14
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Prunetin

Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor[1][2].

  • CAS Number: 552-59-0
  • MF: C16H12O5
  • MW: 284.263
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 546.5±50.0 °C at 760 mmHg
  • Melting Point: 240-242ºC
  • Flash Point: 209.7±23.6 °C

CVT 10216

CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM. CVT-10216 can reduces excessive alcohol drinking in alcohol-preferring rats and exhibits anxiolytic effects[1].

  • CAS Number: 1005334-57-5
  • MF: C24H19NO7S
  • MW: 465.475
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 714.2±70.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 385.8±35.7 °C

Lacto-N-fucopentaose III

Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation[1].

  • CAS Number: 25541-09-7
  • MF: C32H55NO25
  • MW: 853.77
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: 1.71g/cm3
  • Boiling Point: 1264.6ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 718.6ºC

CM 10

CM10 is a potent and selective aldehyde dehydrogenase 1A family inhibitor (ALDH1Ai), with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity[1].

  • CAS Number: 692269-09-3
  • MF: C20H23N3O
  • MW: 321.42
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: 1.12±0.1 g/cm3(Predicted)
  • Boiling Point: 512.4±52.0 °C(Predicted)
  • Melting Point: N/A
  • Flash Point: N/A

ALDH1A2-IN-1

ALDH1A2-IN-1 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.91 μM; Kd=0.26 μM) with several hydrophobic interactions[1].

  • CAS Number: 2204229-64-9
  • MF: C21H26N4O4S
  • MW: 430.52
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

3-Hydroxybenzaldehyde

3-Hydroxybenzaldehyde is a precursor compound for phenolic compounds, such as Protocatechualdehyde (HY-N0295). 3-Hydroxybenzaldehyde is a substrate of aldehyde dehydrogenase (ALDH) in rats and humans (ALDH2). 3-Hydroxybenzaldehyde has vasculoprotective effects in vitro and in vivo[1].

  • CAS Number: 100-83-4
  • MF: C7H6O2
  • MW: 122.121
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 240.9±13.0 °C at 760 mmHg
  • Melting Point: 100-103 °C(lit.)
  • Flash Point: 98.6±12.4 °C

Alda 1

Alda-1 is a potent ALDH2 agonist, which activates wild-type ALDH2 and restores near wild-type activity to ALDH2*2.

  • CAS Number: 349438-38-6
  • MF: C15H11Cl2NO3
  • MW: 324.15900
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

NCT-505

NCT-505 is a potent and selective aldehyde dehydrogenase (ALDH1A1) inhibitor, with an IC50 of 7 nM, and weakly inhibits hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 (IC50s, >57, 22.8, 20.1, >57 μM).

  • CAS Number: 2231079-74-4
  • MF: C27H28FN5O3S
  • MW: 521.61
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Disulfiram

Disulfiram is a specific inhibitor of?aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol.

  • CAS Number: 97-77-8
  • MF: C10H20N2S4
  • MW: 296.539
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 369.0±25.0 °C at 760 mmHg
  • Melting Point: 69-71 °C(lit.)
  • Flash Point: 177.0±23.2 °C

NCT-506

NCT-506 is an orally bioavailable aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with an IC50 of 7 nM[1].

  • CAS Number: 2231098-99-8
  • MF: C25H23FN4O3S
  • MW: 478.54
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

4-isopropoxybenzaldehyde

ALDH1A3-IN-3 (compound 16) is a potent inhibitor of ALDH1A3, with an IC50 of 0.26 μM. ALDH1A3-IN-3 is also a good ALDH3A1 substrate. ALDH1A3-IN-3 can be used for the research of prostate cancer[1].

  • CAS Number: 18962-05-5
  • MF: C10H12O2
  • MW: 164.20100
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: 1.036
  • Boiling Point: 108-110 °C (5 mmHg)
  • Melting Point: N/A
  • Flash Point: 108-110°C/5mm

KS100

KS100 is a potent ALDH inhibitor with IC50s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase[1].

  • CAS Number: 2408477-54-1
  • MF: C17H14Br3N3O2S
  • MW: 564.09
  • Catalog: Apoptosis
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

4-Chloro-2-(cyclopropylmethoxy)-N-(3-fluoro-4-methoxybenzyl)nicotinamide

ALDH2 modulator 1 is a potent and orally active aldehyde dehydrogenase-2 (ALDH2) modulator. ALDH2 modulator 1 reduces blood alcohol levels in mice[1].

  • CAS Number: 1629615-99-1
  • MF: C18H18ClFN2O3
  • MW: 364.80
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

IGUANA-1

IGUANA-1 is a potent inhibitor of ALDH1B1, which is a mitochondrial enzyme that promotes colorectal and pancreatic cancer. IGUANA-1 has significant inhibition against cancer cells[1].

  • CAS Number: 2756014-25-0
  • MF: C27H26ClN3O4
  • MW: 491.97
  • Catalog: Aldehyde Dehydrogenase (ALDH)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A