1695970-90-1
1695970-90-1 structure
- Name: ALDH1A3-IN-1
- Chemical Name: ALDH1A3-IN-1
- CAS Number: 1695970-90-1
- Molecular Formula: C13H18BrNO
- Molecular Weight: 284.19
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldehyde Dehydrogenase (ALDH)
- Create Date: 2022-05-24 18:18:32
- Modify Date: 2024-01-10 19:46:30
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ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC50 of 0.63 µM and a Ki of 0.46 µM. ALDH1A3-IN-1 can be studied in prostate cancer[1].
| Name | ALDH1A3-IN-1 |
|---|
| Description | ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC50 of 0.63 µM and a Ki of 0.46 µM. ALDH1A3-IN-1 can be studied in prostate cancer[1]. |
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| Related Catalog | |
| Target |
ALDH1A3:0.63 μM (IC50) ALDH1A1:7.08 μM (IC50) ALDH3A1:8.00 μM (IC50) ALDH1A3:0.46 μM (Ki) ALDH1A3:26.92 μM (Km) |
| In Vitro | ALDH1A3-IN-1 (Compound 14) (0-200 µM, 96 h) shows antiproliferative activity in prostate cancer cell lines[1]. ALDH1A3-IN-1 (0-200 µM, 72 h) reduces cell viability of primary prostate cells in a dose-dependent manner[1]. Cell Proliferation Assay[1] Cell Line: PC3, LNCaP, and DU145 cells Concentration: 12.5-200 µM Incubation Time: 96 h Result: Showed antiproliferative activity with IC50 values of 47 ± 6, 25 ± 1, and 61 ± 5 µM against PC3, LNCaP, and DU145 cells. Cell Viability Assay[1] Cell Line: Primary cells cultured at early passage from human prostate tissue biopsies Concentration: 50 and 200 μM Incubation Time: 72 h Result: Resulted a dose-dependent reduction in percentage cell viability of primary prostate epithelial cultures. |
| References |
| Molecular Formula | C13H18BrNO |
|---|---|
| Molecular Weight | 284.19 |