Renin is a central hormone in the control of blood pressure and various other physiological functions. Renin is a hormone and an enzyme which chops the end off angiotensinogen, a circulating plasma peptide, thus creating thedecapeptide, angiotensin I. Angiotensin I is acted on by angiotensin converting enzyme (ACE), which chops another bit off to make the octapeptide, angiotensin II. Angiotensin II acts on the adrenal cortex to stimulate the release of aldosterone and aldosterone stimulates Na+ retention. Renin is rate limiting in the production of angiotensin II (Ang II), a hormone that ultimately integrates cardiovascular and renal function in the control of blood pressure as well as salt and volume homeostasis. For instance, renin seems to be of vast importance for maintaining arterial blood pressure in the face of variations in salt intake: in mice, constant blood pressure is found during alterations in sodium intake, and this relies on controlling the activity of the renin-angiotensin system (RAS).


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Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC trifluoroacetate salt

Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC (Renin Substrate I) is a renin substrate[1]

  • CAS Number: 76524-84-0
  • MF: C66H88N14O14
  • MW: 1301.49000
  • Catalog: Renin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Remikiren

Remikiren (Ro 42-5892) is an orally active and highly specific renin inhibitor. Remikiren specifically inhibits human reninand human plasma renin with IC50 values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension[1].

  • CAS Number: 126222-34-2
  • MF: C33H50N4O6S
  • MW: 630.83800
  • Catalog: Renin
  • Density: 1.241g/cm3
  • Boiling Point: 970.2ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 540.6ºC

PD 132002

PD 132002 is an orally active, potent renin inhibitor. PD 132002 weakly inhibits pepsin. PD 132002 produces substantial reductions in blood pressure[1].

  • CAS Number: 134452-04-3
  • MF: C31H50N4O9S
  • MW: 654.81500
  • Catalog: Renin
  • Density: 1.28g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

PD125754

PD125754 is an oligopeptide renin inhibitor (IC50: 22 nM)[1].

  • CAS Number: 124339-32-8
  • MF: C42H65N5O7
  • MW: 751.99500
  • Catalog: Renin
  • Density: 1.14g/cm3
  • Boiling Point: 993.2ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 554.5ºC

VTP-27999 (Hydrochloride)

VTP-27999 Hcl is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.IC50 value:Target: Renin

  • CAS Number: 1264191-73-2
  • MF: C26H42Cl2N4O5
  • MW: 561.54100
  • Catalog: Renin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Aliskiren fumarate

Aliskiren fumarate is an orally active, highly potent and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren fumarate can be used for the research of hypertension, cardiovascular diseases and cancer cachexia[1][2][3].

  • CAS Number: 1196835-68-3
  • MF: C34H57N3O10
  • MW: 667.83
  • Catalog: Autophagy
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Aliskiren hemifumarate

Aliskiren hemifumarate(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM.IC50 value: 1.5 nM [1]Target: reninin vitro: Aliskiren hemifumarate appears to bind to both the hydrophobic S1/S3-binding pocket and to a large, distinct subpocket that extends from the S3-binding site towards the hydrophobic core of renin. Oral bioavailability of Aliskiren hemifumarate is 2.4% in rats, 16% in marmosets and about 2.5% in humans [2].in vivo: Aliskiren hemifumarate (< 10 mg/kg, oral) inhibits plasma renin activity and lowers blood pressure in sodium-depleted marmosets[3].Once-daily oral treatment with Aliskiren hemifumarate lowers blood pressure effectively, with a safety and tolerability profile, in patients with mild-to-moderate hypertension[4].

  • CAS Number: 173334-58-2
  • MF: C64H110N6O16
  • MW: 1219.59000
  • Catalog: Autophagy
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 72-75?C
  • Flash Point: N/A

Aliskiren

Aliskiren(CGP 60536) is a direct renin inhibitor with IC50 of 1.5 nM.IC50 value: 1.5 nM [1]Target: reninin vitro: Aliskiren hemifumarate appears to bind to both the hydrophobic S1/S3-binding pocket and to a large, distinct subpocket that extends from the S3-binding site towards the hydrophobic core of renin. Oral bioavailability of Aliskiren hemifumarate is 2.4% in rats, 16% in marmosets and about 2.5% in humans [2].in vivo: Aliskiren hemifumarate (< 10 mg/kg, oral) inhibits plasma renin activity and lowers blood pressure in sodium-depleted marmosets[3].Once-daily oral treatment with Aliskiren hemifumarate lowers blood pressure effectively, with a safety and tolerability profile, in patients with mild-to-moderate hypertension[4].

  • CAS Number: 173334-57-1
  • MF: C30H53N3O6
  • MW: 551.758
  • Catalog: Autophagy
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 748.4±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 406.4±32.9 °C

Aliskiren D6 Hydrochloride

Aliskiren D6 Hydrochloride is is deuterium labeled Aliskiren, which is a direct renin inhibitor with IC50 of 1.5 nM.

  • CAS Number: 1246815-96-2
  • MF: C30H48D6ClN3O6
  • MW: 594.26
  • Catalog: Renin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Chikusetsusaponin IV

Araloside A (Chikusetsusaponin IV) is a component of Panax japonicus, with low-renin-inhibitory activity, with an IC50 of 77.4 μM[1].

  • CAS Number: 7518-22-1
  • MF: C47H74O18
  • MW: 927.080
  • Catalog: Renin
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 999.1±65.0 °C at 760 mmHg
  • Melting Point: 196-200℃
  • Flash Point: 285.6±27.8 °C

ACT 178882

ACT 178882 is a new Renin inhibitor with an IC50 of 1.4 nM.

  • CAS Number: 1007392-69-9
  • MF: C33H38Cl3N3O4
  • MW: 647.031
  • Catalog: Renin
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 764.3±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 416.0±32.9 °C

VTP 27999 trifluoroacetate

VTP-27999 2,2,2-trifluoroacetate is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.Ic50 value:Target: Renin

  • CAS Number: 1013937-63-7
  • MF: C28H42ClF3N4O7
  • MW: 639.10400
  • Catalog: Renin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

PD 125967

PD 125967 is an oligopeptide renin inhibitor. PD125967 can be used to low blood pressure[1].

  • CAS Number: 128139-14-0
  • MF: C51H67N5O4
  • MW: 814.11
  • Catalog: Renin
  • Density: 1.14g/cm3
  • Boiling Point: 1072.1ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 602.2ºC

SQ 32970

SQ 32970 is a potent Endothia aspartic proteinase inhibitor.

  • CAS Number: 122280-12-0
  • MF: C33H51N5O4S
  • MW: 613.86
  • Catalog: Renin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Renin inhibitor peptide,rat

Renin inhibitor peptide,rat is a biological active peptide. (A specific rat renin inhibitor.)

  • CAS Number: 115290-00-1
  • MF: C50H72N10O9
  • MW: 957.17
  • Catalog: Renin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Bopindolol Malonate

Bopindolol ((±)-Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a prodrug of Pindolol (HY-B0982). Bopindolol malonate can be used for essential and renovascular hypertension research[1][2][3][4].

  • CAS Number: 82857-38-3
  • MF: C23H28N2O3
  • MW: 380.48000
  • Catalog: 5-HT Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Handle region peptide, rat

Handle region peptide, rat is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.

  • CAS Number: 749227-53-0
  • MF: C54H101N15O12S
  • MW: 1184.54
  • Catalog: Peptides
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Renin Substrate 1 trifluoroacetate salt

Renin substrate 1 is a Renin substrate with high affinity to the enzyme[1].

  • CAS Number: 791068-69-4
  • MF: C109H156N32O21S
  • MW: 2282.672
  • Catalog: Renin
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Terlakiren

Terlakiren (CP-80,794) is an orally active inhibitor of renin. Terlakiren inhibits the efficacy of human renin with an IC50 value of 0.7 nM. Terlakiren has potential applications in hypertension[1].

  • CAS Number: 119625-78-4
  • MF: C31H48N4O7S
  • MW: 620.80
  • Catalog: Renin
  • Density: 1.205g/cm3
  • Boiling Point: 908.3ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 503.1ºC

SPH3127

SPH3127 (DRI 18) is a novel, highly potent, and orally active direct renin inhibitor (recombinant human-renin IC50=0.4 nM, human plasma renin activity IC50=0.45 nM). SPH3127 shows antihypertensive effect and can be used in essential hypertension research[1].

  • CAS Number: 1399849-02-5
  • MF: C22H32N6O4
  • MW: 444.53
  • Catalog: Renin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Renin inhibitor-1

Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases[1].

  • CAS Number: 1093082-54-2
  • MF: C22H30N4O4
  • MW: 414.50
  • Catalog: Renin
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Enalkiren

Enalkiren (A-64662) is a potent dipeptide renin inhibitor with an IC50 of 0.78 nM in a purified renal renin-angiotensinogen system (pH=6.0). Enalkiren suppresses renin activity, and also reduces systolic and diastolic blood pressure. Enalkiren can be used to research essential hypertension[1][2].

  • CAS Number: 113082-98-7
  • MF: C35H56N6O6
  • MW: 656.85600
  • Catalog: Renin
  • Density: 1.172g/cm3
  • Boiling Point: 986.3ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 550.3ºC

Lyciumin A

Lyciumin A, a cyclic octapeptide, exhibits inhibitory activity on proteases, renin and angiotensin-converting enzyme. Lyciumin A can be used for the research of hypertension[1][2].

  • CAS Number: 125708-06-7
  • MF: C42H51N9O12
  • MW: 873.90700
  • Catalog: Angiotensin-converting Enzyme (ACE)
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Aliskiren Hydrochloride

Aliskiren (CGP 60536; CGP60536B; SPP 100) hydrochloride is an orally active and selective renin inhibitor, with IC50 of 1.5 nM. Aliskiren hydrochloride can be used for the research of hypertension, cardiovascular diseases and cancer cachexia[1]-[4].

  • CAS Number: 173399-03-6
  • MF: C30H54ClN3O6
  • MW: 588.21900
  • Catalog: Autophagy
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

VTP-27999

VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.Ic50 value:Target: Renin

  • CAS Number: 942142-51-0
  • MF: C26H41ClN4O5
  • MW: 525.08100
  • Catalog: Renin
  • Density: 1.178g/cm3
  • Boiling Point: 703.1ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 379ºC

PD 134922

PD 134922 is a potent renin and HIV-1 protease inhibitor with an IC50 of 15 nM against HIV-1 protease[1].

  • CAS Number: 150351-30-7
  • MF: C37H61N5O7S
  • MW: 719.97500
  • Catalog: HIV Protease
  • Density: 1.19g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Isovaleryl-Phe-Nle-Sta-Ala-Sta-OH

SR 42128 is a potent renin inhibitor. SR 42128 potently inhibits primate renins whereas other animal renins are much less inhibited[1].

  • CAS Number: 98092-14-9
  • MF: C39H65N5O9
  • MW: 747.96100
  • Catalog: Renin
  • Density: 1.138±0.06 g/cm3 (20 °C, 760 mmHg)
  • Boiling Point: 1064.9±65.0 °C (760 mmHg)
  • Melting Point: N/A
  • Flash Point: N/A