Handle region peptide, rat

Modify Date: 2024-01-11 17:29:48

Handle region peptide, rat structure	Common Name	Handle region peptide, rat
	CAS Number	749227-53-0	Molecular Weight	1184.54
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₄H₁₀₁N₁₅O₁₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Handle region peptide, rat

Handle region peptide, rat is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.

Name	Handle region peptide, rat

Description	Handle region peptide, rat is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Renin Research Areas >> Inflammation/Immunology Peptides
Target	Prorenin receptor[1]
In Vitro	Handle region peptide, rat is a (pro)renin receptor antagonist. Handle region peptide, rat (1 μM) reduces the ratio of active to total ERK1/2. Handle region peptide, rat (0.1-1 μM) reduces TGF-β1 mRNA level, and inhibits the mesangial cells proliferation in a dose-dependent manner. Handle region peptide, rat (0.01-1 μM) increases the MMP-2 activity[1].
In Vivo	Handle region peptide, rat (0.1 mg/kg) suppresses leukocyte adhesion in the endotoxin-induced uveitis (EIU) retina, and decreases the leukocyte counts in rats. Handle region peptide, rat (0.1 mg/kg) lowers the protein concentration in EIU rats induced by LPS, and reduces the mRNA expression and the protein levels of inflammatory mediators such as ICAM-1, CCL2/MCP-1, and IL-6 in rats[2].
Cell Assay	The immortalized rat glomerular mesangial cells are incubated at 37°C in Dulbecco's modified Eagle medium (DMEM) supplemented with 10% bovine calf serum (BCS) in a humidified atmosphere of 95% air plus 5% CO2. When the cell reaches about 80% confluence, they are made quiescent by decreasing BCS to 0.5% for 24 to 48 h. To detect the effect of Handle region peptide on p44/42 MAP kinase, the cells are further cultured in serum-deprived medium for 24 h before 1 µM Handle region peptide is added in. The cells are harvested at 0, 1, 5, 10, 60, 120 min time points after Handle region peptide application. Protein isolated from cell lyses is used for subsequent Western blotting analysis[1].
Animal Admin	Rats[2] Long-Evans rats (5-7 weeks old) are treated with 0.1-mL intraperitoneal injections of vehicle (PBS) or Handle region peptide (0.1 or 0.01 mg/kg body weight) the day before and immediately after the injection of LPS. The effects of Handle region peptide treatment on ocular inflammation are evaluated 24 hours after LPS injection[2].
References	[1]. He M, et al. Inhibition of renin/prorenin receptor attenuated mesangial cell proliferation and reduced associated fibrotic factor release. Eur J Pharmacol. 2009 Mar 15;606(1-3):155-61. [2]. Satofuka S, et al. Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin. Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2686-92.

Molecular Formula	C₅₄H₁₀₁N₁₅O₁₂S
Molecular Weight	1184.54
Storage condition	2-8℃

DC Chemicals Limited
China
Product Name: Handle region peptide, rat
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

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