1093082-54-2

1093082-54-2 structure
1093082-54-2 structure
  • Name: Renin inhibitor-1
  • Chemical Name: Renin inhibitor-1
  • CAS Number: 1093082-54-2
  • Molecular Formula: C22H30N4O4
  • Molecular Weight: 414.50
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Renin
  • Create Date: 2022-09-10 18:50:29
  • Modify Date: 2024-01-02 17:21:26
  • Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases[1].

Name Renin inhibitor-1
Description Renin inhibitor-1 (compound 26) is a potent and orally active renin inhibitor with IC50s of 0.9, 1.8 nM for rh-renin and hPRA, respectively. Renin inhibitor-1 shows antihypertensive efficacy. Renin inhibitor-1 has the potential for the research of hypertension and cardiovascular/renal diseases[1].
Related Catalog
Target

IC50: 0.9 nM (rh-renin); 1.8 nM (hPRA)[1]

In Vivo Renin inhibitor-1 (compound 26) (10 mg/kg; p.o.) demonstrates a significantly potent hypotensive effect in tsukuba hypertensive mice[1].
References

[1]. Daisuke Iijima, et al. Discovery of Novel 2-Carbamoyl Morpholine Derivatives as Highly Potent and Orally Active Direct Renin Inhibitors. ACS Med. Chem. Lett. 2022, 13, 8, 1351–1357.

Molecular Formula C22H30N4O4
Molecular Weight 414.50