134452-04-3

134452-04-3 structure

Name: PD 132002
Chemical Name: methyl (2R)-2-[[(2S,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-3-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]-3-oxopropanoate
CAS Number: 134452-04-3
Molecular Formula: C₃₁H₅₀N₄O₉S
Molecular Weight: 654.81500
Catalog: Signaling Pathways Metabolic Enzyme/Protease Renin
Create Date: 2017-09-07 14:32:43
Modify Date: 2024-01-02 11:04:58
PD 132002 is an orally active, potent renin inhibitor. PD 132002 weakly inhibits pepsin. PD 132002 produces substantial reductions in blood pressure[1].

Name	methyl (2R)-2-[[(2S,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-3-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]-3-oxopropanoate
Synonyms	methyl <1S-(1R,2S,3R)>-3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-N-<N-(4-morpholinylsulfonyl)-L-phenylalanyl>-3-oxo-DL-alaninate (1S-(1R,2S,3R))-3-{[1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]amino}-N-[N-(4-morpholinosulfonyl)-L-phenylalanyl]-3-oxo-DL-alanine methyl ester 2-methoxy-6-[(4-methylphenyl)sulfonyloxymethyl]oxane-3,4,5-triol

Description	PD 132002 is an orally active, potent renin inhibitor. PD 132002 weakly inhibits pepsin. PD 132002 produces substantial reductions in blood pressure[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Renin
References	[1]. J T Repine, et al. Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate. J Med Chem. 1991 Jul;34(7):1935-43.