PD 132002

Modify Date: 2024-01-02 11:04:58

PD 132002 Structure
PD 132002 structure
Common Name PD 132002
CAS Number 134452-04-3 Molecular Weight 654.81500
Density 1.28g/cm3 Boiling Point N/A
Molecular Formula C31H50N4O9S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PD 132002


PD 132002 is an orally active, potent renin inhibitor. PD 132002 weakly inhibits pepsin. PD 132002 produces substantial reductions in blood pressure[1].

 Names

Name methyl (2R)-2-[[(2S,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-3-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]-3-oxopropanoate
Synonym More Synonyms

 PD 132002 Biological Activity

Description PD 132002 is an orally active, potent renin inhibitor. PD 132002 weakly inhibits pepsin. PD 132002 produces substantial reductions in blood pressure[1].
Related Catalog
References

[1]. J T Repine, et al. Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate. J Med Chem. 1991 Jul;34(7):1935-43.  

 Chemical & Physical Properties

Density 1.28g/cm3
Molecular Formula C31H50N4O9S
Molecular Weight 654.81500
Exact Mass 654.33000
PSA 195.47000
LogP 3.28600
Index of Refraction 1.579

 Synonyms

methyl <1S-(1R*,2S*,3R*)>-3-<<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>amino>-N-<N-(4-morpholinylsulfonyl)-L-phenylalanyl>-3-oxo-DL-alaninate
(1S-(1R*,2S*,3R*))-3-{[1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]amino}-N-[N-(4-morpholinosulfonyl)-L-phenylalanyl]-3-oxo-DL-alanine methyl ester
2-methoxy-6-[(4-methylphenyl)sulfonyloxymethyl]oxane-3,4,5-triol
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