Isovaleryl-Phe-Nle-Sta-Ala-Sta-OH

Modify Date: 2024-01-21 14:10:56

Isovaleryl-Phe-Nle-Sta-Ala-Sta-OH Structure
Isovaleryl-Phe-Nle-Sta-Ala-Sta-OH structure
Common Name Isovaleryl-Phe-Nle-Sta-Ala-Sta-OH
CAS Number 98092-14-9 Molecular Weight 747.96100
Density 1.138±0.06 g/cm3 (20 °C, 760 mmHg) Boiling Point 1064.9±65.0 °C (760 mmHg)
Molecular Formula C39H65N5O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Isovaleryl-Phe-Nle-Sta-Ala-Sta-OH


SR 42128 is a potent renin inhibitor. SR 42128 potently inhibits primate renins whereas other animal renins are much less inhibited[1].

 Names

Name L-Alaninamide, N-(3-methyl-1-oxobutyl)-L-phenylalanyl-L-norleucyl-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-N-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]
Synonym More Synonyms

 Isovaleryl-Phe-Nle-Sta-Ala-Sta-OH Biological Activity

Description SR 42128 is a potent renin inhibitor. SR 42128 potently inhibits primate renins whereas other animal renins are much less inhibited[1].
Related Catalog
References

[1]. M De Claviere, et al. In vitro and in vivo inhibition of human and primate renin by a new potent renin inhibitor: SR 42128. J Cardiovasc Pharmacol. 1985:7 Suppl 4:S58-61.  

 Chemical & Physical Properties

Density 1.138±0.06 g/cm3 (20 °C, 760 mmHg)
Boiling Point 1064.9±65.0 °C (760 mmHg)
Molecular Formula C39H65N5O9
Molecular Weight 747.96100
Exact Mass 747.47800
PSA 223.26000
LogP 4.54260

 Synonyms

Isovaleryl-Phe-Nle-Sta-Ala-Sta-OH
Pepstatin A, 1-[N-(3-methyl-1-oxobutyl)-L-phenylalanine]-2-L-norleucine-
L-Norleucinamide, N-(3-methyl-1-oxobutyl)-L-phenylalanyl-N-[4-[[2-[[1-(2-carboxy-1-hydroxyethyl)-3-methylbutyl]amino]-1-methyl-2-oxoethyl]amino]-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-, [1S-[1R*,2R*,4[R*[R*(R*)]]]]-
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