A natural product is a chemical compound or substance produced by a living organism-that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis) and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets. Natural products sometimes have therapeutic benefit as traditional medicines for treating diseases, yielding knowledge to derive active components as lead compounds for drug discovery. The term natural product has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients.


Anti-infection >
Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HIV HSV Influenza Virus Parasite Reverse Transcriptase RSV SARS-CoV
Antibody-drug Conjugate >
ADC Cytotoxin ADC Linker Drug-Linker Conjugates for ADC PROTAC-linker Conjugate for PAC
Apoptosis >
Apoptosis Bcl-2 Family c-Myc Caspase DAPK Ferroptosis IAP MDM-2/p53 PKD RIP kinase Survivin Thymidylate Synthase TNF Receptor
Autophagy >
Autophagy LRRK2 ULK Mitophagy
Cell Cycle/DNA Damage >
Antifolate APC ATM/ATR Aurora Kinase Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA-PK DNA/RNA Synthesis Eukaryotic Initiation Factor (eIF) G-quadruplex Haspin Kinase HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 Nucleoside Antimetabolite/Analog p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 ROCK Sirtuin SRPK Telomerase TOPK Topoisomerase Wee1
Cytoskeleton >
Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK
Epigenetics >
AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MicroRNA PARP PKC Sirtuin Protein Arginine Deiminase
GPCR/G Protein >
5-HT Receptor Adenosine Receptor Adenylate Cyclase Adiponectin Receptor Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR Dopamine Receptor EBI2/GPR183 Endothelin Receptor GHSR Glucagon Receptor Glucocorticoid Receptor GNRH Receptor GPCR19 GPR109A GPR119 GPR120 GPR139 GPR40 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR MCHR1 (GPR24) Melatonin Receptor mGluR Motilin Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor Prostaglandin Receptor Protease-Activated Receptor (PAR) Ras RGS Protein Sigma Receptor Somatostatin Receptor TSH Receptor Urotensin Receptor Vasopressin Receptor Melanocortin Receptor
Immunology/Inflammation >
Aryl Hydrocarbon Receptor CCR Complement System COX CXCR FLAP Histamine Receptor IFNAR Interleukin Related IRAK MyD88 NO Synthase NOD-like Receptor (NLR) PD-1/PD-L1 PGE synthase Salt-inducible Kinase (SIK) SPHK STING Thrombopoietin Receptor Toll-like Receptor (TLR) Arginase
JAK/STAT Signaling >
EGFR JAK Pim STAT
MAPK/ERK Pathway >
ERK JNK KLF MAP3K MAP4K MAPKAPK2 (MK2) MEK Mixed Lineage Kinase MNK p38 MAPK Raf Ribosomal S6 Kinase (RSK)
Membrane Transporter/Ion Channel >
ATP Synthase BCRP Calcium Channel CFTR Chloride Channel CRAC Channel CRM1 EAAT2 GABA Receptor GlyT HCN Channel iGluR Monoamine Transporter Monocarboxylate Transporter Na+/Ca2+ Exchanger Na+/HCO3- Cotransporter Na+/K+ ATPase nAChR NKCC P-glycoprotein P2X Receptor Potassium Channel Proton Pump SGLT Sodium Channel TRP Channel URAT1
Metabolic Enzyme/Protease >
15-PGDH 5 alpha Reductase 5-Lipoxygenase Acetyl-CoA Carboxylase Acyltransferase Adenosine Deaminase Adenosine Kinase Aldehyde Dehydrogenase (ALDH) Aldose Reductase Aminopeptidase Angiotensin-converting Enzyme (ACE) ATGL ATP Citrate Lyase Carbonic Anhydrase Carboxypeptidase Cathepsin CETP COMT Cytochrome P450 Dipeptidyl Peptidase Dopamine β-hydroxylase E1/E2/E3 Enzyme Elastase Enolase FAAH FABP Factor Xa Farnesyl Transferase Fatty Acid Synthase (FAS) FXR Glucokinase GSNOR Gutathione S-transferase HCV Protease Hexokinase HIF/HIF Prolyl-Hydroxylase HIV Integrase HIV Protease HMG-CoA Reductase (HMGCR) HSP Indoleamine 2,3-Dioxygenase (IDO) Isocitrate Dehydrogenase (IDH) Lactate Dehydrogenase LXR MAGL Mineralocorticoid Receptor Mitochondrial Metabolism MMP Nampt NEDD8-activating Enzyme Neprilysin PAI-1 PDHK PGC-1α Phosphatase Phosphodiesterase (PDE) Phospholipase Procollagen C Proteinase Proteasome Pyruvate Kinase RAR/RXR Renin ROR Ser/Thr Protease SGK Stearoyl-CoA Desaturase (SCD) Thrombin Tryptophan Hydroxylase Tyrosinase Xanthine Oxidase
Neuronal Signaling >
5-HT Receptor AChE Adenosine Kinase Amyloid-β Beta-secretase CaMK CGRP Receptor COMT Dopamine Receptor Dopamine Transporter FAAH GABA Receptor GlyT iGluR Imidazoline Receptor mAChR Melatonin Receptor Monoamine Oxidase nAChR Neurokinin Receptor Opioid Receptor Serotonin Transporter γ-secretase
NF-κB >
NF-κB IKK Keap1-Nrf2 MALT1
PI3K/Akt/mTOR >
Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN
PROTAC >
PROTAC E3 Ligase Ligand-Linker Conjugate Ligand for E3 Ligase PROTAC Linker PROTAC-linker Conjugate for PAC
Protein Tyrosine Kinase/RTK >
Ack1 ALK Bcr-Abl BMX Kinase Btk c-Fms c-Kit c-Met/HGFR Discoidin Domain Receptor DYRK EGFR Ephrin Receptor FAK FGFR FLT3 IGF-1R Insulin Receptor IRAK Itk PDGFR PKA Pyk2 ROS Src Syk TAM Receptor Trk Receptor VEGFR
Stem Cell/Wnt >
Casein Kinase ERK Gli GSK-3 Hedgehog Hippo (MST) JAK Notch Oct3/4 PKA Porcupine ROCK sFRP-1 Smo STAT TGF-beta/Smad Wnt YAP β-catenin γ-secretase
TGF-beta/Smad >
TGF-beta/Smad PKC ROCK TGF-β Receptor
Vitamin D Related >
VD/VDR
Others >
Androgen Receptor Aromatase Estrogen Receptor/ERR Progesterone Receptor Thyroid Hormone Receptor Others
Scopine structure

Scopine

Scopine is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock. Target: α1-Adrenergic ReceptorScopine is a tropane alkaloid found in a variety of plants including Mandragora root, Senecio mikanoides (Delairea odorata), Scopolia carniolica and Scopolia lurida. Scopine can be prepared by the hydrolysis of scopolamine. From Wikipedia.

  • CAS Number: 498-45-3
  • MF: C8H13NO2
  • MW: 155.194
  • Catalog: Adrenergic Receptor
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 281.3±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 123.9±27.3 °C
Amrubicin (hydrochloride) structure

Amrubicin (hydrochloride)

Amrubicin hydrochloride is a DNA topoisomerase II inhibitor, used for the research of cancer.

  • CAS Number: 110311-30-3
  • MF: C25H26ClNO9
  • MW: 519.92800
  • Catalog: Cancer
  • Density: N/A
  • Boiling Point: 717.8ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 387.9ºC
Diosmin structure

Diosmin

Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).

  • CAS Number: 520-27-4
  • MF: C28H32O15
  • MW: 608.545
  • Catalog: Aryl Hydrocarbon Receptor
  • Density: 1.7±0.1 g/cm3
  • Boiling Point: 926.8±65.0 °C at 760 mmHg
  • Melting Point: 277-278°C
  • Flash Point: 305.2±27.8 °C
3-Indolepropionic acid structure

3-Indolepropionic acid

3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.

  • CAS Number: 830-96-6
  • MF: C11H11NO2
  • MW: 189.210
  • Catalog: Metabolic Disease
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 417.6±20.0 °C at 760 mmHg
  • Melting Point: 134-135 °C(lit.)
  • Flash Point: 206.4±21.8 °C
D-arabinitol structure

D-arabinitol

Arabinitol, D- is a polyol and its accumulation may cause a neurotoxic effect in human.

  • CAS Number: 488-82-4
  • MF: C5H12O5
  • MW: 152.146
  • Catalog: Metabolic Disease
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 494.5±40.0 °C at 760 mmHg
  • Melting Point: 101-104ºC
  • Flash Point: 261.9±21.9 °C
Cimifugin structure

Cimifugin

Cimifugin is a major components of Yu-ping-feng-san, a Chinese medical formula that is used clinically for allergic diseases and characterized by reducing allergy relapse.

  • CAS Number: 37921-38-3
  • MF: C16H18O6
  • MW: 306.310
  • Catalog: Others
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 546.4±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 204.9±23.6 °C
L-arginine structure

L-arginine

L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersL-Arginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.

  • CAS Number: 74-79-3
  • MF: C6H14N4O2
  • MW: 174.201
  • Catalog: NO Synthase
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 367.6±52.0 °C at 760 mmHg
  • Melting Point: 222 °C (dec.)(lit.)
  • Flash Point: 176.1±30.7 °C
Enoxolone structure

Enoxolone

18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

  • CAS Number: 471-53-4
  • MF: C30H46O4
  • MW: 470.684
  • Catalog: Cancer
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 588.3±50.0 °C at 760 mmHg
  • Melting Point: 292 - 295ºC
  • Flash Point: 323.7±26.6 °C
Deoxycholic acid structure

Deoxycholic acid

Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

  • CAS Number: 83-44-3
  • MF: C24H40O4
  • MW: 392.572
  • Catalog: GPCR19
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 547.1±35.0 °C at 760 mmHg
  • Melting Point: 171-174 °C(lit.)
  • Flash Point: 298.8±22.4 °C
Hydroxypyruvic acid structure

Hydroxypyruvic acid

Hydroxypyruvic acid is an intermediate in the metabolism of Glycine, serine and threonine. It is a substrate for Serine--pyruvate aminotransferase and Glyoxylate reductase/hydroxypyruvate reductase.

  • CAS Number: 1113-60-6
  • MF: C3H4O4
  • MW: 104.06100
  • Catalog: Others
  • Density: 1.546g/cm3
  • Boiling Point: 252.9ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 121ºC
Ureidopropionic acid structure

Ureidopropionic acid

Ureidopropionic acid is an intermediate in the metabolism of uracil.

  • CAS Number: 462-88-4
  • MF: C4H8N2O3
  • MW: 132.11800
  • Catalog: Others
  • Density: 1.337g/cm3
  • Boiling Point: 324.8ºC at 760mmHg
  • Melting Point: 170-175ºC (dec.)
  • Flash Point: 150.2ºC
Oxyresveratrol structure

Oxyresveratrol

Oxyresveratrol is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. It effectively scavenges H2O2, NO (IC50 = 45.3 μM), and the artificial free radical 2,2-diphenyl-l-picrylhydrazyl (IC50 = 28.9 μM) In vitro: 1)oxyresveratrol exhibited more than 50% inhibition at 100 μM on L-tyrosine oxidation by murine tyrosinase activity.2) oxyresveratrol showed an IC50 value of 52.7 μM on the enzyme activity. 3) oxyresveratrol works through reversible inhibition of tyrosinase activity rather than suppression of the expression and synthesis of the enzyme.[2] In vivo: 1) Oxyresveratrol (10 or 20 mg/kg) significantly reduced the brain infarct volume by approximately 54% and 63%, respectively, when compared to vehicle-treated MCAO rats.2) oxyresveratrol treatment diminished cytochrome c release and decreasedcaspase-3 activation in MCAO rats. [3]

  • CAS Number: 29700-22-9
  • MF: C14H12O4
  • MW: 244.243
  • Catalog: Autophagy
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 523.8±30.0 °C at 760 mmHg
  • Melting Point: 201ºC
  • Flash Point: 260.8±19.2 °C
Triptophenolide structure

Triptophenolide

Triptophenolide is a colorless crystalline plate isolated from ethyl acetate extracts of Tripterygium wilfordii. IC50 value:Target:In vitro: Triptophenolide can remarkably inhibit the delayed type hypersensitivity (DTH) reaction induced by DNCB and BSA; and diminished the peripheral blood ANAE+lymphocytes in rats and micc. Moreover, triptophenolide can dramatically increase the amount of total serum complement and significautly decrcase the serum antibody products (1gG ) of rats and mice. The phagocytosis of perioneal exudate macrophages in mice present double effects in vitro [1].In vivo:

  • CAS Number: 74285-86-2
  • MF: C20H24O3
  • MW: 312.403
  • Catalog: Others
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 490.0±45.0 °C at 760 mmHg
  • Melting Point: 232-233ºC
  • Flash Point: 202.4±21.5 °C
Docosatrienoic acid structure

Docosatrienoic acid

Docosatrienoic acid is a rare ω-3 fatty acid; inhibits LTB4 binding to pig neutrophil membranes with an Ki of 5 μM.

  • CAS Number: 28845-86-5
  • MF: C22H38O2
  • MW: 334.536
  • Catalog: Others
  • Density: 0.9±0.1 g/cm3
  • Boiling Point: 459.1±14.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 355.8±15.2 °C
Veratric acid structure

Veratric acid

Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].

  • CAS Number: 93-07-2
  • MF: C9H10O4
  • MW: 182.173
  • Catalog: Cardiovascular Disease
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 302.9±22.0 °C at 760 mmHg
  • Melting Point: 179-182 °C(lit.)
  • Flash Point: 120.9±15.8 °C
S-Methyl-L-cysteine structure

S-Methyl-L-cysteine

S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.

  • CAS Number: 1187-84-4
  • MF: C4H9NO2S
  • MW: 135.185
  • Catalog: Others
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 242.8±30.0 °C at 760 mmHg
  • Melting Point: ~240 °C (dec.)
  • Flash Point: 100.7±24.6 °C
D(+)-Glucose structure

D(+)-Glucose

Dextrose, a simple sugar (monosaccharide), is an important carbohydrate in biology.Target: OthersDextrose(D-glucose), a simple sugar (monosaccharide), is an important carbohydrate in biology.

  • CAS Number: 50-99-7
  • MF: C6H12O6
  • MW: 180.156
  • Catalog: Metabolic Disease
  • Density: 1.6±0.1 g/cm3
  • Boiling Point: 527.1±50.0 °C at 760 mmHg
  • Melting Point: 146 ºC
  • Flash Point: 286.7±26.6 °C
capsaicin structure

capsaicin

Capsaicin is a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells.

  • CAS Number: 404-86-4
  • MF: C18H27NO3
  • MW: 305.412
  • Catalog: Autophagy
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 469.7±55.0 °C at 760 mmHg
  • Melting Point: 62-65 °C(lit.)
  • Flash Point: 237.9±31.5 °C
Inositol structure

Inositol

i-Inositol is a chemical compound, associated lipids are found in many foods, in particular fruit, especially cantaloupe and oranges.

  • CAS Number: 87-89-8
  • MF: C6H12O6
  • MW: 180.156
  • Catalog: Others
  • Density: 2.0±0.1 g/cm3
  • Boiling Point: 291.3±40.0 °C at 760 mmHg
  • Melting Point: 220-228ºC
  • Flash Point: 143.4±21.9 °C
Paclitaxel structure

Paclitaxel

Paclitaxel is a potent anticancer medication which can promote microtubule (MT) assembly, inhibit MT depolymerization, and change MT dynamics required for mitosis and cell proliferation.

  • CAS Number: 33069-62-4
  • MF: C47H51NO14
  • MW: 853.906
  • Catalog: ADC Cytotoxin
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 957.1±65.0 °C at 760 mmHg
  • Melting Point: 213 °C (dec.)(lit.)
  • Flash Point: 532.6±34.3 °C
Loureirin A structure

Loureirin A

Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity.

  • CAS Number: 119425-89-7
  • MF: C17H18O4
  • MW: 286.322
  • Catalog: Cardiovascular Disease
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 479.1±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 175.8±20.8 °C
Arctiin structure

Arctiin

Arctiin(NSC 315527), a plant lignan that can be extracted from the Arctium lappa (burdock) seeds, is a possible environmental endocrine disruptor compounds and have been shown to influence sex hormone metabolism as well as protein synthesis, steroid biosynthesis. IC50 Value:Target: Othersin vitro: Treatment of PC-3 cells with arctiin decreased the cell number in a concentration- and time-dependent manner in serum-containing condition. Arctiin preferentially induced cell detachment, but did not have anti-proliferation or cytotoxic effects in PC-3 cells. The arctiin-induced effect was inhibited by cycloheximide, indicating that protein synthesis was required [1]. Although arctiin, the active component of AL that has been described in the literature, was not able to reduce degranulation in RBL-2H3 cells, a single high-performance liquid chromatography (HPLC) fraction from the AL extract inhibited beta-hexosaminidase release (IC(50) = 22.2 microg/ml) [2]. The growth inhibition caused by arctiin is associated with the down-regulation of cyclin D1 protein expression. Furthermore, thearctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer. Depletion of the cyclin D1 protein using small interfering RNA-rendered human breast cancer MCF-7 cells insensitive to the growth inhibitory effects of arctiin, implicates cyclin D1 as an important target of arctiin [6]. in vivo: Histopathological evaluation of prostate revealed that all the rats in any group developed adenocarcinoma in dorsolateral lobe of prostate, except two rats in 0.1% arctiin treated and one rat in 0.002% arctiin treated groups without prostate adenocarcinoma development [3]. After oral administration of arctiin (30, 60, 120 mg/kgd) for three weeks, the levels of serum creatinine (Scr) and blood urea nitrogen (BUN) and 24-h urine protein content markedly decreased, while endogenous creatinine clearance rate (ECcr) significantly increased [4]. STZ-induced diabetic rats were treated witharctiin at the dosage of 60 or 40 mg/kg/day via intraperitoneal injection for 8 weeks. Blood glucose and 24-h urinary albumin content were measured, and kidney histopathological changes were monitored [5].

  • CAS Number: 20362-31-6
  • MF: C27H34O11
  • MW: 534.552
  • Catalog: Cancer
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 756.4±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 250.1±26.4 °C
Brassinolide structure

Brassinolide

Brassinolide is a predominant plant growth modulator that regulate plant cell elongation.

  • CAS Number: 72962-43-7
  • MF: C28H48O6
  • MW: 480.677
  • Catalog: Cancer
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 633.7±55.0 °C at 760 mmHg
  • Melting Point: 200-204ºC
  • Flash Point: 202.3±25.0 °C
Kinetin structure

Kinetin

Kinetin (N6-furfuryladenine) belongs to a group of plant growth hormones involved in cell division, differentiation and other physiological processes.IC50 Value: Target:Kinetin is one of the widely used components in numerous skin care cosmetics and cosmeceuticals, such as Valeant products kinerase. Recently, kinetin has the potential to be a treatment for the human splicing disease familial dysautonomia.in vitro: Kinetin-induced cell death reflected by the morphological changes of nuclei including their invagination, volume increase, chromatin condensation and degradation as well as formation of micronuclei showed by AO/EB and 4,6-diamidino-2-phenylindol staining was accompanied by changes including increase in conductivity of cell electrolytes secreted to culture media, decrease in the number of the G1- and G2-phase cells and appearance of fraction of hypoploid cells as the effect of DNA degradation without ladder formation [1]. The plant cytokinin kinetin dramatically increases exon 20 inclusion in RNA isolated from cultured FD cells [3].in vivo: Subjects received 23.5 mg/Kg/d for 28 d. An increase in WT IKBKAP mRNA expression in leukocytes was noted after 8 d in six of eight individuals; after 28 d, the mean increase compared with baseline was significant (p = 0.002) [2].Toxicity: On mice with leukaemia P388, kinetin has no effect on the tumour growth, and it appears to be toxic at the dose of 25 mg/kg [4].

  • CAS Number: 525-79-1
  • MF: C10H9N5O
  • MW: 215.211
  • Catalog: Neurological Disease
  • Density: 1.6±0.1 g/cm3
  • Boiling Point: 367.6±52.0 °C at 760 mmHg
  • Melting Point: 269-271 °C (dec.)(lit.)
  • Flash Point: 176.1±30.7 °C
Pi-Methylimidazoleacetic acid structure

Pi-Methylimidazoleacetic acid

Pi-Methylimidazoleacetic acid is a potential neurotoxin.

  • CAS Number: 4200-48-0
  • MF: C6H8N2O2
  • MW: 140.14000
  • Catalog: Others
  • Density: 1.27g/cm3
  • Boiling Point: 384.4ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 186.3ºC
5Z-7-Oxozeaenol structure

5Z-7-Oxozeaenol

5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of 8 nM and 52 nM, respectively.

  • CAS Number: 253863-19-3
  • MF: C19H22O7
  • MW: 362.37400
  • Catalog: MAP3K
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
Isoastragaloside IV structure

Isoastragaloside IV

Isoastragaloside IV is a triterpene oligoglycoside isolated from Astragali Radix.

  • CAS Number: 136033-55-1
  • MF:
  • MW:
  • Catalog: Others
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
Squalene structure

Squalene

Squalene is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, cardioprotective, antioxidant, and antitoxicant activity.

  • CAS Number: 111-02-4
  • MF: C30H50
  • MW: 410.718
  • Catalog: Cardiovascular Disease
  • Density: 0.8±0.1 g/cm3
  • Boiling Point: 429.3±0.0 °C at 760 mmHg
  • Melting Point: −75 °C(lit.)
  • Flash Point: 254.1±22.2 °C
foresaconitine structure

foresaconitine

Foresaconitine(Vilmorrianine C) is a norditerpenoid alkaloid isolated from the processed tubers of Aconitum carmichaeli.

  • CAS Number: 73870-35-6
  • MF: C35H49NO9
  • MW: 627.765
  • Catalog: Others
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 663.4±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 355.0±31.5 °C
Bulleyaconitine A structure

Bulleyaconitine A

Bulleyaconitine A is an analgesic and antiinflammatory drug isolated from Aconitum plants; has several potential targets, including voltage-gated Na+ channels.

  • CAS Number: 107668-79-1
  • MF: C35H49NO9
  • MW: 627.765
  • Catalog: Sodium Channel
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 690.9±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 371.7±31.5 °C