BioBioPha
China
Product Name: 4-Hydroxyphenylacetic acid
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4-Hydroxyphenylacetic acid
Price: ￥198.0/20mg ￥478.0/500g ￥128.0/100g
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Hydroxyphenylacetic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-Hydroxyphenylacetic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

156-38-7

156-38-7 structure

156-38-7 structure

Name: 4-Hydroxyphenylacetic acid
Chemical Name: 4-hydroxyphenylacetic acid
CAS Number: 156-38-7
Molecular Formula: C₈H₈O₃
Molecular Weight: 152.147
Catalog: Natural product Phenols
Create Date: 2018-08-14 23:07:11
Modify Date: 2024-01-02 10:00:09
4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].

Name	4-hydroxyphenylacetic acid
Synonyms	4-Hydroxyphenyl acetic acid 2-(4-Hydroxyphenyl)acetic acid 4-hydroxyphenylacetic acid (p-hydroxyphenyl)-Acetic acid (4-Hydroxy-phenyl)-acetic acid 4-Hydroxy-Benzeneacetic acid (4-Hydroxyphenyl)acetic acid MFCD00004347 Benzeneacetic acid, 4-hydroxy- EINECS 205-851-3 PHPA

Description	4-hydroxyphenylacetic acid, a major microbiota-derived metabolite of polyphenols, is involved in the antioxidative action. 4-hydroxyphenylacetic acid induces expression of Nrf2[1].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Natural Products >> Phenols Research Areas >> Metabolic Disease
Target	Nrf2[1]
In Vivo	4-Hydroxyphenylacetic acid (6, 12, or 25 mg/kg) increases Nrf2 translocation to the nucleus and enhances the activity of phase II and antioxidant enzymes. The protein levels of nuclear Nrf2 are increased by 170% and 230% in pre-treated 12 and 25 mg/kg 4-Hydroxyphenylacetic acid groups, respectively, compared with the control group.The 4-Hydroxyphenylacetic acid pretreatment at a final dose of 25 mg/kg markedly and selectively up-regulated the target genes of phase II enzymes and resulted in higher up-regulation than that of the control group by 270%, 400%, and 500% or UGT1A1, UGT1A9, and SULT2A1, respectively. 4-Hydroxyphenylacetic acid also suppresses the expression of CYP2E1[1].
References	[1]. Zhao H, et al. 4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase IIand Antioxidant Enzymes in Mice. Front Pharmacol. 2018 Jun 19;9:653.

Density	1.3±0.1 g/cm3
Boiling Point	346.6±17.0 °C at 760 mmHg
Melting Point	148-151 °C(lit.)
Molecular Formula	C₈H₈O₃
Molecular Weight	152.147
Flash Point	177.6±17.4 °C
Exact Mass	152.047348
PSA	57.53000
LogP	0.77
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.596

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AI2680000

CHEMICAL NAME :: Acetic acid, (p-hydroxyphenyl)-

CAS REGISTRY NUMBER :: 156-38-7

BEILSTEIN REFERENCE NO. :: 1448766

LAST UPDATED :: 199803

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H8-O3

MOLECULAR WEIGHT :: 152.16

WISWESSER LINE NOTATION :: QV1R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 13,286,1958

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AI2680000
HS Code	2918290000

Precursor 10
501-94-0 104-01-8 14191-95-8 58609-13-5
52449-43-1 17194-82-0 182296-61-3 150-30-1
14199-15-6 2491-38-5
DownStream 9
110005-81-7 55453-87-7 55779-48-1 33697-81-3
52798-01-3 537-42-8 40784-88-1 3413-59-0
56715-13-0

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%