BioBioPha
China
Product Name: 4-Hydroxyphenyl ethanol
Price: ￥Inquiry/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4-Hydroxyphenyl ethanol
Price: ￥468.0/100g ￥158.0/25g ￥348.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 4-Hydroxyphenethyl alcohol
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Hydroxyphenethyl alcohol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 2-(4-hydroxyphenyl)ethanol
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

501-94-0

501-94-0 structure

501-94-0 structure

Name: 4-Hydroxyphenyl ethanol
Chemical Name: 2-(4-hydroxyphenyl)ethanol
CAS Number: 501-94-0
Molecular Formula: C₈H₁₀O₂
Molecular Weight: 138.16
Catalog: Chemical reagent Organic reagent Aromatic alcohol
Create Date: 2018-08-21 16:01:36
Modify Date: 2024-01-01 19:00:44
Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects[1].

Name	2-(4-hydroxyphenyl)ethanol
Synonyms	4-(2-Hydroxyethyl)phenol 2-(4-Hydroxyphenyl)ethyl Alcohol 4-Hydroxyphenylethanol β-(4-Hydroxyphenyl)ethanol 4-[(2S)-2-Amino-3-hydroxypropyl]phenol (S)-4-(2-Amino-3-hydroxypropyl)phenol b-(4-Hydroxyphenyl)ethanol Benzenepropanol, β-amino-4-hydroxy-, (βS)- tyrosinol 4-(2-Hydroxyethyl)benzolol phenethyl alcohol, 4-hydroxy- p-Hydroxyphenethyl alcohol Benzenepropanol, β-amino-4-hydroxy-, (S)- UNII-1AK4μ3SNX 2-(4-Hydroxyphenyl)ethanol Ethanol, 2-(4-hydroxyphenyl)- 2-(4-Hydroxyphenyl)ethan-1-ol (S)-b-Amino-4-hydroxybenzenepropanol 4-hydroxybenzeneethanol MFCD00002902 β-(p-Hydroxyphenyl)ethanol 4-Hydroxyphenethyl alcohol EINECS 207-930-8 Benzeneethanol, 4-hydroxy- p-Hydroxyphenylethanol 4-Hydroxyphenethyl alcohol,Tyrosol,p-HPEA 4-Hydroxyphenylethyl alcohol b-(p-Hydroxyphenyl)ethanol 4-Hydroxyphenyl ethanol Tyrosol

Description	Tyrosol is a derivative of phenethyl alcohol. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation. Anti-oxidative and anti-inflammatory effects[1].
Related Catalog	Signaling Pathways >> NF-κB >> NF-κB Natural Products >> Phenols Research Areas >> Inflammation/Immunology
In Vitro	Tyrosol (1.6 mM) significantly increases the cell viability of cultured astrocytes exposed to oxygen glucose deprivation (OGD)[1]. Tyrosol (1.6 mM) attenuates the released TNF-α and IL-6 level from astrocyte via regulating Janus N-terminal kinase (JNK) [1]. The reduction of cytokines from astrocyte might be due to its inhibition of astrocyte activation and regulation of STAT3 signaling pathway since Tyrosol (1.6 mM) attenuates the expression level of GFAP (glial fibrillary acidic protein) and the phosphorylation of STAT3[1]. Tyrosol prevents the degradation of IκBα and the increase of IκBα phosphorylation in astrocytes exposed to OGD, which leads to the suppression of NF-κB function during ischemia[1].
In Vivo	Sub-plantar injection of carrageenan causes a noticeable increase in paw thickness, reaching a peak after 2 h post-injection. This effect is reduced when Tyrosol (0.5 mg/kg) or Tyrosol-sulphate is injected prior to the treatment with carrageenan. Similar AUC values for paw oedema are obtained after the administration of Tyrosol at a dose of 0.5 mg/kg and Tyrosol-sulphate at a dose of 0.1 mg/kg.
References	[1]. Luo G, et al. Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation in in vitro oxygen glucose deprivation. Neurochem Int. 2018 Dec;121:140-145. [2]. Muriana FJG, et al. Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells. Food Funct. 2017 Aug 1;8(8):2905-2914.

Density	1.2±0.1 g/cm3
Boiling Point	375.2±27.0 °C at 760 mmHg
Melting Point	89-92 °C(lit.)
Molecular Formula	C₈H₁₀O₂
Molecular Weight	138.16
Flash Point	180.7±23.7 °C
PSA	40.46000
LogP	0.04
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.598
Water Solubility	slightly soluble

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2907299090

Precursor 9
156-38-7 14199-15-6 60-12-8 1223454-88-3
17138-28-2 104-01-8 14140-15-9 60-18-4
35897-92-8
DownStream 8
110005-81-7 40167-10-0 56718-71-9 181115-01-5
28145-35-9 93221-48-8 81024-42-2 836-43-1

HS Code	2907299090
Summary	2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%