Monoamine transporters (MATs) are protein structures that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine neurotransmitters. Three major classes of MATs (SERT, DAT, NET) are responsible for the reuptake of their associated amine neurotransmitters (serotonin, dopamine, norepinephrine). MATs are located just outside the synaptic cleft (peri-synaptically), transporting monoamine transmitter overflow from the synaptic cleft back to the cytoplasm of the pre-synaptic neuron. MAT regulation generally occurs throughphosphorylation and posttranslational modification. Due to their significance in neuronal signaling, MATs are commonly associated with drugs used to treat mental disorders as well as recreational drugs. Compounds targeting MATs range from medications such as the wide variety of tricyclic antidepressants, selective serotonin reuptake inhibitors to stimulantmedications and amphetamine.


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13-Hydroxyisobakuchiol

Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) isolated from Psoralea corylifolia (L.), is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50=0.58 μM) and norepinephrine transporter (NET) (IC50=0.69 μM) than for the serotonin transporter (SERT) (IC50=312.02 μM). 13-Hydroxyisobakuchiol has the potential for the research of disorders such as Parkinson's disease, depression, and cocaine addiction[1].

  • CAS Number: 178765-49-6
  • MF: C18H24O2
  • MW: 272.382
  • Catalog: Monoamine Transporter
  • Density: 1.0±0.1 g/cm3
  • Boiling Point: 429.3±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 195.8±23.3 °C

Tetrabenazine D6

Tetrabenazine D6 is the deuterium labeled Tetrabenazine, which is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder.

  • CAS Number: 1392826-25-3
  • MF: C19H21D6NO3
  • MW: 323.46000
  • Catalog: Monoamine Transporter
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Tetrabenazine

Tetrabenazine is a VMAT-inhibitor used for treatment of hyperkinetic movement disorder.Target: Otherstetrabenazine (TBZ), a monoamine-depleting and a dopamine-receptor-blocking drug. TBZ is an effective and safe drug for the treatment of a variety of hyperkinetic movement disorders. In contrast to typical neuroleptics, TBZ has not been demonstrated to cause tardive dyskinesia [1, 2]. Twenty patients with tardive dyskinesia (mean duration = 43.7 months) were videotaped before and after tetrabenazine treatment. One patient did not tolerate tetrabenazine owing to sedation. The remaining 19 were rated after a mean of 20.3 weeks at a mean tetrabenazine dose of 57.9 mg/day. There were significant improvements in mean scores on both the patient AIMS self-rating and the AIMS motor subset evaluated by the blind videotape raters. All 19 patients continued to take tetrabenazine after the study [3].

  • CAS Number: 58-46-8
  • MF: C19H27NO3
  • MW: 317.423
  • Catalog: Monoamine Transporter
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 448.9±45.0 °C at 760 mmHg
  • Melting Point: 128-130ºC
  • Flash Point: 225.3±28.7 °C

FFN511

FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 µM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices[1][2].

  • CAS Number: 1004548-96-2
  • MF: C17H20N2O2
  • MW: 284.353
  • Catalog: Monoamine Transporter
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 538.5±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 279.5±30.1 °C

Tetrabenazine (Racemate)

Tetrabenazine (Racemate) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2).(1) The reference for administration is 0.25-0.75 mg/kg IP(2) Injections of tetrabenazine into accumbens core also reduced FR5 lever pressing and increased chow intake. (3) Tetrabenazine (Racemate) reduced extracellular DA and altered DARPP-32 signaling in both substance-P- and enkephalin-containing accumbens neurons. (4) Tetrabenazine (Racemate) inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice.

  • CAS Number: 718635-93-9
  • MF: C19H27NO3
  • MW: 317.42300
  • Catalog: Monoamine Transporter
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

GZ-793A

GZ-793A is an orally active and selective vesicular monoamine transporter-2 (VMAT2) inhibitor, with an Ki of 0.029 µM. GZ-793A inhibits the neurochemical effects of methamphetamine (METH)-induced dopamine release. GZ-793A can be used for research of METH addiction[1][2][3].

  • CAS Number: 1356447-90-9
  • MF: C26H38ClNO4
  • MW: 464.037
  • Catalog: Monoamine Transporter
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Reserpine hydrochloride

Reserpine hydrochloride is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).

  • CAS Number: 16994-56-2
  • MF: C33H41ClN2O9
  • MW: 645.14000
  • Catalog: Monoamine Transporter
  • Density: N/A
  • Boiling Point: 700.1ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 377.2ºC

(3S,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydrobenzo[a]quinolizin-2-one,methanesulfonic acid

Tetrabenazine (Ro 1-9569) mesylate is a reversible inhibitor of the vesicular monoamine transporter VMAT2 with the Kd value of 1.34 nM. Tetrabenazine mesylate can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease[1][2][3].

  • CAS Number: 804-53-5
  • MF: C20H31NO6S
  • MW: 413.52800
  • Catalog: Monoamine Transporter
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Cavα2δ1&NET-IN-1

Cavα2δ1&NET-IN-1 (Compound 59S) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-1 inhibits Cavα2δ-1 with a Ki of 112 nM. Cavα2δ1&NET-IN-1 inhibits NET with a Ki of 383 nM and IC50 of 67 nM. Cavα2δ1&NET-IN-1 can be used for research of pain[1].

  • CAS Number: 2314361-39-0
  • MF: C23H26N4O2S
  • MW: 422.54
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Nisoxetine

Nisoxetine is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.76 nM. Nisoxetine is an antidepressant and local anesthetic, it can block voltage-gated sodium channels[1][2][3].

  • CAS Number: 53179-07-0
  • MF: C17H21NO2
  • MW: 271.35400
  • Catalog: Monoamine Transporter
  • Density: 1.054g/cm3
  • Boiling Point: 404.8ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 170.6ºC

(±)-Tetrabenazine

Tetrabenazine ((+)-) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1. target: VMAT-2In vitro: Tetrabenazine ((+)-) inhibit the activity of the transporter but appear to interact differently with the protein. [2] Tetrabenazine ((+)-) inhibits reserpine binding to the transporter, suggesting that the sites may interact in an allosteric manner. [1]In vivo: 0.9% saline (80%) and dimethylsulfoxide (DMSO) (20%). Tetrabenazine ((+)-) blocks dopamine (DA) storage and depletes striatal DA; Tetrabenazine ((+)-) was shown to induce tremulous jaw movements (TJMs) in rats and mice. The reference dose for administration is 2.0 mg/kg.[2]

  • CAS Number: 1026016-83-0
  • MF: C19H27NO3
  • MW: 317.423
  • Catalog: Monoamine Transporter
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 448.9±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 225.3±28.7 °C

Vanilpyruvic acid

Vanilpyruvic acid is a catecholamine metabolite and precursor to vanillactic acid.

  • CAS Number: 1081-71-6
  • MF: C10H10O5
  • MW: 210.18300
  • Catalog: Adrenergic Receptor
  • Density: 1.374g/cm3
  • Boiling Point: 402ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 162.1ºC

Cavα2δ1&NET-IN-2

Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-2 inhibits Cavα2δ-1 with a Ki of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a Ki of 59 nM and IC50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain[1].

  • CAS Number: 2143586-17-6
  • MF: C22H26N6O2S
  • MW: 438.55
  • Catalog: Calcium Channel
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

NBI-98782

NBI-98782(alpha-dihydrotetrabenazine) is a vesicular monoamine transporter (VMAT2) inhibtior with an Ki value of 0.97 nM.IC50 value: 0.97± 0.48 nM [1]Target: VMAT2 The (+)-isomer showed high affinity in vitro (Ki = 0.97 +/- 0.48 nM) for the vesicular monoamine transporter (VMAT2) in rat brain striatum, whereas the (-)-isomer was inactive (Ki = 2.2 +/- 0.3 microM). Each isomer was then synthesized in carbon-11 labeled form, and regional brain biodistributions in mice determined after intravenous injection.

  • CAS Number: 85081-18-1
  • MF: C19H29NO3
  • MW: 319.439
  • Catalog: Monoamine Transporter
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 457.8±45.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 230.7±28.7 °C

FFN246

Novel fluorescent substrate for both the serotonin transporter and the vesicular monoamine transporter 2 (VMAT2)

  • CAS Number: 2210244-83-8
  • MF: C15H14ClFN2O
  • MW: 292.74
  • Catalog: 5-HT Receptor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

NBI-98854

NBI-98854 is a potent, highly selective, VMAT2 inhibitor that is effective in regulating the levels of dopamine release during nerve communication.IC50 value:Target: VMAT2NBI-98854 completed a Phase I single ascending dose clinical trial in healthy male volunteers in Canada under an approved Clinical Trial Application with Health Canada.This trial showed NBI-98854 to be generally safe and well tolerated.

  • CAS Number: 171598-74-6
  • MF: C19H29NO3
  • MW: 319.44
  • Catalog: Monoamine Transporter
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 167-170°C
  • Flash Point: N/A

Nisoxetine hydrochloride

Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenaline transporter (NET), with a Kd of 0.61 nM. Nisoxetine hydrochloride is an antidepressant and local anesthetic, it can block voltage-gated sodium channels[1][2][3].

  • CAS Number: 57754-86-6
  • MF: C17H22ClNO2
  • MW: 307.81500
  • Catalog: Monoamine Transporter
  • Density: 1.054g/cm3
  • Boiling Point: 404.8ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 170.6ºC

(+)-Tetrabenazine D6

(+)-Tetrabenazine D6 is the deuterium labeled (+)-Tetrabenazine. (+)-Tetrabenazine is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2).

  • CAS Number: 1977511-05-9
  • MF: C19H21D6NO3
  • MW: 323.46
  • Catalog: Monoamine Transporter
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A

Reserpine

Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).

  • CAS Number: 50-55-5
  • MF: C33H40N2O9
  • MW: 608.679
  • Catalog: Monoamine Transporter
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 700.1±60.0 °C at 760 mmHg
  • Melting Point: 265ºC (dec.)
  • Flash Point: 377.2±32.9 °C

(S,S)-Hydroxy Bupropion

Radafaxine ((S,S)-Hydroxybupropion) is an antidepressant. Radafaxine blocks dopamine transporters (DAT). Radafaxine is an active metabolite of Bupropion[1][2].

  • CAS Number: 192374-14-4
  • MF: C13H18ClNO2
  • MW: 255.74
  • Catalog: Monoamine Transporter
  • Density: 1.144g/cm3
  • Boiling Point: 386.574ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 187.594ºC

1,1'-Diethyl-2,2'-cyanine iodide

Pseudoisocyanine (iodide) is a pan inhibitor of monoamine transporters and organic cation transporters with antidepressant-like activity[1].

  • CAS Number: 977-96-8
  • MF: C23H23IN2
  • MW: 454.34700
  • Catalog: Monoamine Transporter
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 273ºC
  • Flash Point: N/A

Radafaxine (hydrochloride)

Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator.

  • CAS Number: 106083-71-0
  • MF: C13H19Cl2NO2
  • MW: 292.20100
  • Catalog: Monoamine Transporter
  • Density: 1.144g/cm3
  • Boiling Point: 386.6ºC at 760mmHg
  • Melting Point: N/A
  • Flash Point: 187.6ºC

Tetrabenazine Metabolite

Tetrabenazine Metabolite is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a high affinity (Ki=13.4 nM)[1]. Tetrabenazine Metabolite is be developed for the treatment of chorea associated with Huntington’s disease and other hyperkinetic disorders[1].

  • CAS Number: 924854-60-4
  • MF: C19H29NO3
  • MW: 319.43800
  • Catalog: Monoamine Transporter
  • Density: 1.13±0.1 g/cm3 (20 °C, 760 mmHg)
  • Boiling Point: 457.8±45.0 °C (760 mmHg)
  • Melting Point: N/A
  • Flash Point: N/A

TC-T 6000

hENT4-IN-1 is a potent and selective human ENT4 (equilibrative nucleoside transporter 4) inhibitor with an IC50 of 74.4 nM[1].

  • CAS Number: 949467-71-4
  • MF: C26H48N8O2
  • MW: 504.71
  • Catalog: Monoamine Transporter
  • Density: 1.1±0.1 g/cm3
  • Boiling Point: 660.0±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 352.9±34.3 °C