(S,S)-Hydroxy Bupropion

Modify Date: 2025-08-25 13:33:52

(S,S)-Hydroxy Bupropion structure	Common Name	(S,S)-Hydroxy Bupropion
	CAS Number	192374-14-4	Molecular Weight	255.74
	Density	1.144g/cm3	Boiling Point	386.574ºC at 760 mmHg
	Molecular Formula	C₁₃H₁₈ClNO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	187.594ºC

Use of (S,S)-Hydroxy Bupropion

Radafaxine ((S,S)-Hydroxybupropion) is an antidepressant. Radafaxine blocks dopamine transporters (DAT). Radafaxine is an active metabolite of Bupropion[1][2].

Name	(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol
Synonym	More Synonyms

Description	Radafaxine ((S,S)-Hydroxybupropion) is an antidepressant. Radafaxine blocks dopamine transporters (DAT). Radafaxine is an active metabolite of Bupropion[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Monoamine Transporter
References	[1]. Volkow ND, et al. The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects. Biol Psychiatry. 2005 Mar 15;57(6):640-6. [2]. Xu H, et al. Stereoselective analysis of hydroxybupropion and application to drug interaction studies. Chirality. 2007 Mar;19(3):163-70.

Description

Radafaxine ((S,S)-Hydroxybupropion) is an antidepressant. Radafaxine blocks dopamine transporters (DAT). Radafaxine is an active metabolite of Bupropion[1][2].

Related Catalog

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Monoamine Transporter

References

[1]. Volkow ND, et al. The slow and long-lasting blockade of dopamine transporters in human brain induced by the new antidepressant drug radafaxine predict poor reinforcing effects. Biol Psychiatry. 2005 Mar 15;57(6):640-6.

[2]. Xu H, et al. Stereoselective analysis of hydroxybupropion and application to drug interaction studies. Chirality. 2007 Mar;19(3):163-70.

Density	1.144g/cm3
Boiling Point	386.574ºC at 760 mmHg
Molecular Formula	C₁₃H₁₈ClNO₂
Molecular Weight	255.74
Flash Point	187.594ºC
Exact Mass	291.079285
PSA	41.49000
LogP	3.40280
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.523

Precursor 6
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