Cavα2δ1&NET-IN-2
Modify Date: 2025-09-23 12:31:37
Cavα2δ1&NET-IN-2 structure
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Common Name | Cavα2δ1&NET-IN-2 | ||
|---|---|---|---|---|
| CAS Number | 2143586-17-6 | Molecular Weight | 438.55 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H26N6O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Cavα2δ1&NET-IN-2Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-2 inhibits Cavα2δ-1 with a Ki of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a Ki of 59 nM and IC50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain[1]. |
| Name | Cavα2δ1&NET-IN-2 |
|---|
| Description | Cavα2δ1&NET-IN-2 (Compound 45CS) is a dual inhibitor of the α2δ‑1 subunit of voltage-gated calcium channels (Cavα2δ-1) and the norepinephrine transporter (NET). Cavα2δ1&NET-IN-2 inhibits Cavα2δ-1 with a Ki of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a Ki of 59 nM and IC50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain[1]. |
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| Related Catalog | |
| Target |
Cavα2δ1: 112 nM (Ki); NET: 383 nM (Ki), 67 nM (IC50). |
| References |
| Molecular Formula | C22H26N6O2S |
|---|---|
| Molecular Weight | 438.55 |
| InChIKey | IWLOXSUFFLVQCV-SFHVURJKSA-N |
| SMILES | CNCCC(Oc1cccc(N2CCN(C)c3nc(N)ncc3C2=O)c1)c1cccs1 |