2378617-67-3

2378617-67-3 structure

Name: Integrin-IN-2
Chemical Name: Integrin-IN-2
CAS Number: 2378617-67-3
Molecular Formula: C₂₇H₃₀N₄O₃
Molecular Weight: 458.55
Catalog: Signaling Pathways Cytoskeleton Integrin
Create Date: 2019-12-08 11:39:18
Modify Date: 2024-01-03 16:36:48
Integrin-IN-2 (compound 39) is an orally bioavailable pan αv integrin inhibitor. Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively[1].

Name	Integrin-IN-2

Description	Integrin-IN-2 (compound 39) is an orally bioavailable pan αv integrin inhibitor. Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> Integrin
Target	pIC50: 7.8 (αvβ6), 8.4 (αvβ3), 8.4 (αvβ5) and 7.4 (αvβ8)[1]
In Vivo	In vivo pharmacokinetic studies in CD rats revealed that racemic Integrin-IN-2 (compound 39) has a low plasma clearance of 8 mL/(min kg), a low to moderate volume of distribution of 0.5 L/kg, a moderate halflife of 1.8 h, and very high bioavailability of 98%[1].
References	[1]. Anderson NA, et al. Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis. J Med Chem. 2019 Oct 10;62(19):8796-8808.

Molecular Formula	C₂₇H₃₀N₄O₃
Molecular Weight	458.55