106083-71-0

106083-71-0 structure

Name: Radafaxine (hydrochloride)
Chemical Name: (2S,3S)-Hydroxybupropion hydrochloride
CAS Number: 106083-71-0
Molecular Formula: C₁₃H₁₉Cl₂NO₂
Molecular Weight: 292.20100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Monoamine Transporter
Create Date: 2018-12-21 09:34:38
Modify Date: 2025-08-25 15:05:37
Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator.

Name	(2S,3S)-Hydroxybupropion hydrochloride
Synonyms	(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol,hydrochloride Radafaxine (hydrochloride)

Description	Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Monoamine Transporter Research Areas >> Neurological Disease
References	[1]. Xu H, et al. Stereoselective analysis of hydroxybupropion and application to drug interaction studies. Chirality. 2007 Mar;19(3):163-70. [2]. Bondarev ML, et al. Behavioral and biochemical investigations of bupropion metabolites. Eur J Pharmacol. 2003 Aug 1;474(1):85-93.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport
HS Code	2922509090

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%