Radafaxine (hydrochloride)

Modify Date: 2024-01-06 12:42:55

Radafaxine (hydrochloride) Structure
Radafaxine (hydrochloride) structure
Common Name Radafaxine (hydrochloride)
CAS Number 106083-71-0 Molecular Weight 292.20100
Density 1.144g/cm3 Boiling Point 386.6ºC at 760mmHg
Molecular Formula C13H19Cl2NO2 Melting Point N/A
MSDS Chinese USA Flash Point 187.6ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Radafaxine (hydrochloride)


Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator.

 Names

Name (2S,3S)-Hydroxybupropion hydrochloride
Synonym More Synonyms

 Radafaxine (hydrochloride) Biological Activity

Description Radafaxine Hcl(BW-306U; GW-353162A) is a potent metabolite of bupropion; selective for inhibiting the reuptake of norepinephrine over dopamine; DAT (dopamine transporter) and NET(norepinephrine transporter) transporters inhibitor, and nAChR family modulator.
Related Catalog
References

[1]. Xu H, et al. Stereoselective analysis of hydroxybupropion and application to drug interaction studies. Chirality. 2007 Mar;19(3):163-70.

[2]. Bondarev ML, et al. Behavioral and biochemical investigations of bupropion metabolites. Eur J Pharmacol. 2003 Aug 1;474(1):85-93.

 Chemical & Physical Properties

Density 1.144g/cm3
Boiling Point 386.6ºC at 760mmHg
Molecular Formula C13H19Cl2NO2
Molecular Weight 292.20100
Flash Point 187.6ºC
Exact Mass 291.07900
PSA 41.49000
LogP 3.40280
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.523
Storage condition 2-8℃

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
RIDADR NONH for all modes of transport
HS Code 2922509090

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethylmorpholin-2-ol,hydrochloride
Radafaxine (hydrochloride)