178765-49-6

178765-49-6 structure

Name: 13-Hydroxyisobakuchiol
Chemical Name: 4-[(1E,3S,5E)-7-Hydroxy-3,7-dimethyl-3-vinyl-1,5-octadien-1-yl]phenol
CAS Number: 178765-49-6
Molecular Formula: C₁₈H₂₄O₂
Molecular Weight: 272.382
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Monoamine Transporter
Create Date: 2018-06-27 07:43:31
Modify Date: 2024-01-02 20:13:05
Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) isolated from Psoralea corylifolia (L.), is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50=0.58 μM) and norepinephrine transporter (NET) (IC50=0.69 μM) than for the serotonin transporter (SERT) (IC50=312.02 μM). 13-Hydroxyisobakuchiol has the potential for the research of disorders such as Parkinson's disease, depression, and cocaine addiction[1].

Name	4-[(1E,3S,5E)-7-Hydroxy-3,7-dimethyl-3-vinyl-1,5-octadien-1-yl]phenol
Synonyms	4-[(1E,3S,5E)-7-Hydroxy-3,7-dimethyl-3-vinyl-1,5-octadien-1-yl]phenol Phenol, 4-[(1E,3S,5E)-3-ethenyl-7-hydroxy-3,7-dimethyl-1,5-octadien-1-yl]-

Description	Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) isolated from Psoralea corylifolia (L.), is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50=0.58 μM) and norepinephrine transporter (NET) (IC50=0.69 μM) than for the serotonin transporter (SERT) (IC50=312.02 μM). 13-Hydroxyisobakuchiol has the potential for the research of disorders such as Parkinson's disease, depression, and cocaine addiction[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Monoamine Transporter
Target	IC50: 0.58 μM (dopamine transporter) IC50: 0.69 μM (norepinephrine transporter)[1]
References	[1]. Gang Zhao, et al. Bakuchiol analogs inhibit monoamine transporters and regulate monoaminergic functions. Biochem Pharmacol. 2008 May 1;75(9):1835-47.