DC Chemicals Limited
China
Product Name: VTP-27999
Price: $750.0/100mg $1500.0/250mg $2900.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

942142-51-0

942142-51-0 structure

Name: VTP-27999
Chemical Name: methyl N-[2-[(R)-(3-chlorophenyl)-[(3R)-1-[[(2S)-2-(methylamino)-3-[(3R)-oxan-3-yl]propyl]carbamoyl]piperidin-3-yl]methoxy]ethyl]carbamate
CAS Number: 942142-51-0
Molecular Formula: C₂₆H₄₁ClN₄O₅
Molecular Weight: 525.08100
Catalog: Signaling Pathways Metabolic Enzyme/Protease Renin
Create Date: 2018-12-04 08:14:17
Modify Date: 2024-01-03 18:03:02
VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.Ic50 value:Target: Renin

Name	methyl N-[2-[(R)-(3-chlorophenyl)-[(3R)-1-[[(2S)-2-(methylamino)-3-[(3R)-oxan-3-yl]propyl]carbamoyl]piperidin-3-yl]methoxy]ethyl]carbamate
Synonyms	Methyl (2-{(R)-(3-Chlorophenyl)[(3r)-1-({(2s)-2-(Methylamino)-3-[(3r)-Tetrahydro-2h-Pyran-3-Yl]propyl}carbamoyl)piperidin-3-Yl]methoxy}ethyl)carbamate Methyl (2-((R)-(3-chlorophenyl)((R)-1-(((S)-2-(methylamino)-3-((R)-tetrahydro-2H-pyran-3-yl)propyl)carbamoyl)piperidin-3-yl)methoxy)ethyl)carbamate QC-4593 VTP-27999

Description	VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.Ic50 value:Target: Renin
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Renin Research Areas >> Cardiovascular Disease
References	[1]. Lanqi Jia et al. Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility ACS Med. Chem. Lett., 2011, 2 (10), pp 747-751 [2]. New renin inhibitor VTP-27999 alters renin immunoreactivity and does not unfold prorenin. Hypertension. 2013 May;61(5):1075-1082.

Density	1.178g/cm3
Boiling Point	703.1ºC at 760 mmHg
Molecular Formula	C₂₆H₄₁ClN₄O₅
Molecular Weight	525.08100
Flash Point	379ºC
Exact Mass	524.27700
PSA	101.16000
LogP	4.69060
Index of Refraction	1.537
Storage condition	2-8℃

1013937-63-7

~91%

942142-51-0

Literature: VITAE PHARMACEUTICALS, INC.; CLAREMON, David, A.; SIMPSON, Robert, D.; JIA, Lanqi Patent: WO2011/17533 A1, 2011 ; Location in patent: Page/Page column 24 ;

Precursor 1
1013937-63-7
DownStream 0