CM121
Modify Date: 2024-01-14 12:16:47
CM121 structure
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Common Name | CM121 | ||
|---|---|---|---|---|
| CAS Number | 2204230-40-8 | Molecular Weight | 460.48 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H17FN4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CM121CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.54 μM；Kd=1.1 μM) with a variety of hydrophobic interactions[1]. |
| Name | CM121 |
|---|
| Description | CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.54 μM；Kd=1.1 μM) with a variety of hydrophobic interactions[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.54 μM (ALDH1A2), Kd: 1.1 μM (ALDH1A2)[1] |
| In Vitro | CM121 interacts with the main-chain amides of Cys320 and Thr321 and the side-chains of Thr321 and Asn187 via methylsulfonyl oxygen. CM121 establishes π-π stacking with the side chains of PHE188 and PHE314 through methylsulfonyl benzene and benzylonitrile rings[1]. |
| References |
| Molecular Formula | C24H17FN4O3S |
|---|---|
| Molecular Weight | 460.48 |