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Product Name: Prunetin
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Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Prunetin
Price: ￥1600.0/5mg
Purity: 98.0%
Stocking Period: 2 Day
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Prunetin
Price: ￥Inquiry/1kg
Purity: 99.5%
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552-59-0

552-59-0 structure

552-59-0 structure

Name: Prunetin
Chemical Name: prunetin
CAS Number: 552-59-0
Molecular Formula: C₁₆H₁₂O₅
Molecular Weight: 284.263
Catalog: Natural product Flavonoids
Create Date: 2018-02-22 08:00:00
Modify Date: 2024-01-04 21:14:52
Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor[1][2].

Name	prunetin
Synonyms	5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one Prunusetin 5,4'-dihydroxy-7-methoxyisoflavone Prunetin 7-methoxy-4',5-dihydroxyisoflavone 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxychromen-4-one 7-O-methyl-genistein 4',5-dihydroxy-7-methoxyisoflavone 4',5-dihydroxy-7-methoxygenistein 4H-1-Benzopyran-4-one, 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy- EINECS 209-018-5 MFCD00016951

Description	Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aldehyde Dehydrogenase (ALDH) Research Areas >> Inflammation/Immunology
In Vitro	Prunetin inhibited LPS-induced inflammatory cytokine production and MUC5 AC expression and secretion by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells[1].
References	[1]. Hu H, et al. Prunetin inhibits lipopolysaccharide-induced inflammatory cytokine production and MUC5AC expression by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells. Biomed Pharmacother. 2018 Oct;106:1469-1477. [2]. Sheikh S, et al. Allosteric inhibition of human liver aldehyde dehydrogenase by the isoflavone prunetin. Biochem Pharmacol. 1997 Feb 21;53(4):471-8.

Density	1.4±0.1 g/cm3
Boiling Point	546.5±50.0 °C at 760 mmHg
Melting Point	240-242ºC
Molecular Formula	C₁₆H₁₂O₅
Molecular Weight	284.263
Flash Point	209.7±23.6 °C
Exact Mass	284.068481
PSA	79.90000
LogP	3.53
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.669

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3100050

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-

CAS REGISTRY NUMBER :: 552-59-0

BEILSTEIN REFERENCE NO. :: 0292155

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H12-O5

MOLECULAR WEIGHT :: 284.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 13,51,1979

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DJ3100050
HS Code	2914509090

Precursor 9
446-72-0 74-88-4 69127-80-6 89595-66-4
1162-82-9 69127-79-3 855829-21-9 56982-36-6
108-73-6
DownStream 2
34086-51-6 156-38-7

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%