Prunetin

Modify Date: 2025-08-21 10:03:54

Prunetin structure	Common Name	Prunetin
	CAS Number	552-59-0	Molecular Weight	284.263
	Density	1.4±0.1 g/cm3	Boiling Point	546.5±50.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₂O₅	Melting Point	240-242ºC
	MSDS	Chinese USA	Flash Point	209.7±23.6 °C

Use of Prunetin

Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor[1][2].

Name	prunetin
Synonym	More Synonyms

Description	Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aldehyde Dehydrogenase (ALDH) Research Areas >> Inflammation/Immunology
In Vitro	Prunetin inhibited LPS-induced inflammatory cytokine production and MUC5 AC expression and secretion by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells[1].
References	[1]. Hu H, et al. Prunetin inhibits lipopolysaccharide-induced inflammatory cytokine production and MUC5AC expression by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells. Biomed Pharmacother. 2018 Oct;106:1469-1477. [2]. Sheikh S, et al. Allosteric inhibition of human liver aldehyde dehydrogenase by the isoflavone prunetin. Biochem Pharmacol. 1997 Feb 21;53(4):471-8.

Density	1.4±0.1 g/cm3
Boiling Point	546.5±50.0 °C at 760 mmHg
Melting Point	240-242ºC
Molecular Formula	C₁₆H₁₂O₅
Molecular Weight	284.263
Flash Point	209.7±23.6 °C
Exact Mass	284.068481
PSA	79.90000
LogP	3.53
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.669

Prunetin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3100050

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-

CAS REGISTRY NUMBER :: 552-59-0

BEILSTEIN REFERENCE NO. :: 0292155

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H12-O5

MOLECULAR WEIGHT :: 284.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 13,51,1979

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DJ3100050
HS Code	2914509090

Precursor 9
CAS#:446-72-0 Genistein CAS#:74-88-4 methyl iodide CAS#:69127-80-6 4'-hydroxy-5,7-... CAS#:89595-66-4 Prunetin 5-O-β-...
CAS#:1162-82-9 GENISTEIN TRIME... CAS#:69127-79-3 2,4'-dihydroxy-... CAS#:855829-21-9 3-(4-amino-phen... CAS#:56982-36-6 2-hydroxy-4,6-d...
CAS#:108-73-6 Phloroglucinol
DownStream 2
CAS#:34086-51-6 7-O-Methylbioch... CAS#:156-38-7 4-Hydroxyphenyl...

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Preparation and evaluation of surface-bonded tricationic ionic liquid silica as stationary phases for high-performance liquid chromatography.

J. Chromatogr. A. 1396 , 62-71, (2015)

Two tricationic ionic liquids were prepared and then bonded onto the surface of supporting silica materials through "thiol-ene" click chemistry as new stationary phases for high-performance liquid chr...

Absorption of red clover isoflavones in human subjects: results from a pilot study.

Br. J. Nutr. 103(11) , 1569-72, (2010)

In addition to soya-derived preparations, red clover-based dietary supplements have gained considerable interest as an alternative isoflavone (IF) source. While metabolism and bioavailability of the m...

The phytoestrogen prunetin affects body composition and improves fitness and lifespan in male Drosophila melanogaster.

FASEB J. 30 , 948-58, (2016)

Dietary isoflavones, a group of secondary plant compounds that exhibit phytoestrogenic properties, are primarily found in soy. Prunetin, a representative isoflavone, was recently found to affect cell ...

5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one

Prunusetin

5,4'-dihydroxy-7-methoxyisoflavone

Prunetin

7-methoxy-4',5-dihydroxyisoflavone

5-hydroxy-3-(4-hydroxyphenyl)-7-methoxychromen-4-one

7-O-methyl-genistein

4',5-dihydroxy-7-methoxyisoflavone

4',5-dihydroxy-7-methoxygenistein

4H-1-Benzopyran-4-one, 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxy-

EINECS 209-018-5

MFCD00016951

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China
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Prunetin
Price: ￥1600.0/5mg
Purity: 98.0%
Delivery: 2 Day
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Prunetin

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HEALTH HAZARD DATA

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