EN40 structure
|
Common Name | EN40 | ||
---|---|---|---|---|
CAS Number | 2094547-67-6 | Molecular Weight | 217.268 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C13H15NO2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of EN40ALDH3A1 inhibitor EN40 is a potent and selective, covalent, in vivo-active inhibitor of ALDH3A1 with IC50 of 2 uM, demonstrates no activity against ALDH1A3 and ALDH6A1 at 30 uM; also does not show any observable competition against lysine-reactive probe labeling of A549 proteomes; specifically inhibits the lung cancer cell lines expressing ALDH3A1, but not in the cell lines that do not express ALDH3A1, inhibits ALDH3A1 activity and impairs lung cancer pathogenicity in vivo. |
Name | ALDH3A1 inhibitor EN40 |
---|
Description | ALDH3A1 inhibitor EN40 is a potent and selective, covalent, in vivo-active inhibitor of ALDH3A1 with IC50 of 2 uM, demonstrates no activity against ALDH1A3 and ALDH6A1 at 30 uM; also does not show any observable competition against lysine-reactive probe labeling of A549 proteomes; specifically inhibits the lung cancer cell lines expressing ALDH3A1, but not in the cell lines that do not express ALDH3A1, inhibits ALDH3A1 activity and impairs lung cancer pathogenicity in vivo. |
---|---|
References | References 1. Counihan JL, et al. ACS Chem Biol. 2018 Jul 13. doi: 10.1021/acschembio.8b00381. View Related Products by Target Aldehyde Dehydrogenase (ALDH) |
Molecular Formula | C13H15NO2 |
---|---|
Molecular Weight | 217.268 |