CM 10
Modify Date: 2024-01-10 14:02:33
CM 10 structure
|
Common Name | CM 10 | ||
|---|---|---|---|---|
| CAS Number | 692269-09-3 | Molecular Weight | 321.42 | |
| Density | 1.12±0.1 g/cm3(Predicted) | Boiling Point | 512.4±52.0 °C(Predicted) | |
| Molecular Formula | C20H23N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CM 10CM10 is a potent and selective aldehyde dehydrogenase 1A family inhibitor (ALDH1Ai), with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity[1]. |
| Name | CM10 |
|---|
| Description | CM10 is a potent and selective aldehyde dehydrogenase 1A family inhibitor (ALDH1Ai), with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM10 does not inhibit any of the other ALDH family members. CM10 can regulate metabolism and has anti-cancer activity[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 1700 nM (ALDH1A1), 740 nM (ALDH1A2) and 640 nM (ALDH1A3)[1] |
| In Vitro | CM10 (12.5, 25, 50, 100 μM; 1 hour) inhibits ALDEFLUOR activity in live cells and preferentially depletes CD133+ ovarian cancer stem-like cells (CSCs)[1]. CM10 induces a cellular/nuclear swelling necroptotic phenotype[1]. |
| References |
| Density | 1.12±0.1 g/cm3(Predicted) |
|---|---|
| Boiling Point | 512.4±52.0 °C(Predicted) |
| Molecular Formula | C20H23N3O |
| Molecular Weight | 321.42 |
| Hazard Codes | Xn |
|---|