NCT-501 hydrochloride
Modify Date: 2024-01-10 16:03:23
NCT-501 hydrochloride structure
|
Common Name | NCT-501 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 2080306-22-3 | Molecular Weight | 452.98 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H33ClN6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NCT-501 hydrochlorideNCT-501 hydrochloride is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM)[1][2]. |
| Name | NCT-501 hydrochloride |
|---|
| Description | NCT-501 hydrochloride is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM)[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 40 nM (hALDH1A1)[2] |
| In Vitro | NCT-501 shows a 16% decrease in the Cal-27 CisR cell line at 20 nM concentration, though the difference was not statistically significant[1]. |
| In Vivo | NCT-501 (100 µg/animal; i.t.; every alternate day for 20 days) shows a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts[1]. |
| References |
| Molecular Formula | C21H33ClN6O3 |
|---|---|
| Molecular Weight | 452.98 |