CM121

Modify Date: 2025-08-28 17:27:49

CM121 structure	Common Name	CM121
	CAS Number	2204230-40-8	Molecular Weight	460.48
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₁₇FN₄O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CM121

CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.54 μM；Kd=1.1 μM) with a variety of hydrophobic interactions[1].

Name	CM121

Description	CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.54 μM；Kd=1.1 μM) with a variety of hydrophobic interactions[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aldehyde Dehydrogenase (ALDH) Research Areas >> Others
Target	IC50: 0.54 μM (ALDH1A2), Kd: 1.1 μM (ALDH1A2)[1]
In Vitro	CM121 interacts with the main-chain amides of Cys320 and Thr321 and the side-chains of Thr321 and Asn187 via methylsulfonyl oxygen. CM121 establishes π-π stacking with the side chains of PHE188 and PHE314 through methylsulfonyl benzene and benzylonitrile rings[1].
References	[1]. Chen Y, et al. Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors. ACS Chem Biol. 2018;13(3):582-590

Molecular Formula	C₂₄H₁₇FN₄O₃S
Molecular Weight	460.48

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