DC Chemicals Limited
China
Product Name: Eltrombopag (SB-497115-GR)
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Eltrombopag
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Eltrombopag
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Eltrombopag free acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

496775-61-2

496775-61-2 structure

496775-61-2 structure

Name: Eltrombopag
Chemical Name: eltrombopag
CAS Number: 496775-61-2
Molecular Formula: C₂₅H₂₂N₄O₄
Molecular Weight: 442.467
Catalog: Signaling Pathways Immunology/Inflammation Thrombopoietin Receptor
Create Date: 2018-03-05 08:00:00
Modify Date: 2024-01-02 11:23:02
Eltrombopag is a thrombopoietin (TPO) receptor agonist developed for certain conditions that lead to thrombocytopenia.

Name	eltrombopag
Synonyms	Eltrombopag 3'-{(2E)-2-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxy-3-biphenylcarboxylic acid 3-[(5E)-5-[[2-(3,4-dimethylphenyl)-5-methyl-3-oxo-1H-pyrazol-4-yl]hydrazinylidene]-6-oxocyclohexa-1,3-dien-1-yl]benzoic acid (E)-Eltrombopag [1,1'-Biphenyl]-3-carboxylic acid, 3'-[(2E)-2-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy- SB-497115-GR

Description	Eltrombopag is a thrombopoietin (TPO) receptor agonist developed for certain conditions that lead to thrombocytopenia.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Thrombopoietin Receptor Research Areas >> Cardiovascular Disease
References	[1]. Erickson-Miller CL, et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells. 2009 Feb;27(2):424-30. [2]. Erickson-Miller CL, et al. Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist. Exp Hematol. 2005 Jan;33(1):85-93. [3]. McHutchison JG, et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med. 2007 Nov 29;357(22):2227-36. [4]. Jenkins JM, et al. Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood. 2007 Jun 1;109(11):4739-41. [5]. Saleh MN, et al. Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study. Blood. 2013 Jan 17;121(3):537-45.

Density	1.3±0.1 g/cm3
Boiling Point	656.8±65.0 °C at 760 mmHg
Melting Point	242-244ºC
Molecular Formula	C₂₅H₂₂N₄O₄
Molecular Weight	442.467
Flash Point	351.0±34.3 °C
Exact Mass	442.164093
PSA	114.59000
LogP	3.70
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.667

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%