Hetrombopag
Modify Date: 2024-01-05 16:00:42
Hetrombopag structure
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Common Name | Hetrombopag | ||
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| CAS Number | 2114365-78-3 | Molecular Weight | 458.474 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H22N4O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HetrombopagHetrombopag is a potent, selective, orally-active Thrombopoietin (TPO) receptor agonist; specifically stimulates proliferation and/or differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells, with low nanomolar EC50 values through stimulation of STAT, PI3K and ERK signalling pathways; specifically enhances the viability and promoted the growth of 32D-MPL cells in hollow fibres implanted in nude mice, exhibiting much higher potency than eltrombopag in vivo. Other Indication Phase 2 Clinical |
| Name | Hetrombopag |
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| Description | Hetrombopag is a potent, selective, orally-active Thrombopoietin (TPO) receptor agonist; specifically stimulates proliferation and/or differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells, with low nanomolar EC50 values through stimulation of STAT, PI3K and ERK signalling pathways; specifically enhances the viability and promoted the growth of 32D-MPL cells in hollow fibres implanted in nude mice, exhibiting much higher potency than eltrombopag in vivo. Other Indication Phase 2 Clinical |
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| References | References 1. Zhou N, et al. Cardiovasc Drugs Ther. 2016 Dec;30(6):567-577. 2. Xie C, et al. J Cell Mol Med. 2018 Nov;22(11):5367-5377. View Related Products by Target Thrombopoietin Receptor (CD110) Other Indication |
| Molecular Formula | C25H22N4O5 |
|---|---|
| Molecular Weight | 458.474 |